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Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin.
TLDR
The results suggest that rhapontigenin is a potent mechanism-based inactivator of human P450 1A1 and may be considered as a good candidate for a cancer chemopreventive agent in humans. Expand
Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.
TLDR
The results in this study suggest both HCA and BCA inhibit the lymphoproliferation and induce a T-cell differentiation through the blockade of early steps in signaling pathway leading to cell growth. Expand
Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.
TLDR
The role of capsaicin is indicated as a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of fibrosarcoma cells. Expand
Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate-activated protein kinase in human HepG2 cells and obese mice.
TLDR
The beneficial effects of AF on HFD-induced hepatic lipid accumulation are thus mediated through AMPK signaling pathways, suggesting a potential target for the prevention of obesity. Expand
Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation
TLDR
This work investigated whether metformin (1,1‐dimethylbiguanide hydrochloride) down‐regulates MDR1 expression in MCF‐7/adriamycin (MCF‐ 7/adr) cells. Expand
Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells.
TLDR
It is suggested that AA induced apoptosis through increased intracellular Ca(2+), which, in turn, enhanced p53 expression in HepG2 cells, and further suggest that AA may be a valuable agent for the therapeutic intervention of human hepatomas. Expand
Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase.
TLDR
Puerarin stimulates eNOS phosphorylation and NO production via activation of an estrogen receptor-mediated PI3K/Akt- and CaMKII/AMPK-dependent pathway and may be useful for the treatment or prevention of endothelial dysfunction associated with diabetes and cardiovascular disease. Expand
Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.
  • M. T. Do, M. Na, +9 authors H. Jeong
  • Chemistry, Medicine
  • Food and chemical toxicology : an international…
  • 1 September 2014
TLDR
It is demonstrated that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimoquinone could be developed into an adjuvant chemotherapeutic drug. Expand
Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells.
TLDR
The results showed that piperine strongly inhibited proliferation and induced apoptosis through caspase-3 activation and PARP cleavage, and suggest that p Piperine may be a potential agent for the prevention and treatment of human breast cancer with HER2 overexpression. Expand
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