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Naming the color of a word: Is it responses or task sets that compete?
Subjects named the colors in which high- and low-frequency words and pronounceable nonwords, otherwise matched, were displayed. Color naming was slower for all three item types than for visuallyExpand
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From artificial evolution to artificial life
This work addresses the question: What are the basic design considerations for creating a synthetic model of the evolution of living systems (i.e. an `arti cial life' system)? It can also be viewed as an attempt to elucidate the logical structure of biological evolution. Expand
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Water quality characteristics of discharge from reforested loose-dumped mine spoil in eastern Kentucky.
Surface mining is a common method for extracting coal in the coal fields of eastern Kentucky. Using the Forestry Reclamation Approach (FRA), which emphasizes the use of minimally compacted orExpand
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Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6.
The relationship between lipophilicity and CYP2D6 affinity of cyclic tertiary (N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines) and quaternary (N-alkyl-4-phenylpyridinium) amines was examined. TheExpand
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Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the
As a plausible explanation for the large interindividual variability in the pharmacokinetics of the neuroleptic agent haloperidol, the contributions of CYP3A isozymes (CYP3A4 and the polymorphicExpand
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On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.
The unexpected occurrence of idiosyncratic drug reactions during late clinical trials or after a drug has been released can lead to a severe restriction in its use or failure to release/withdrawal.Expand
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Disposition of CP-671, 305, a selective phosphodiesterase 4 inhibitor in preclinical species
The disposition of (+)-2-[4-({[2-(benzo[1,3] dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid (CP-671,305), a potent and selective inhibitor of phosphodiesterase 4Expand
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Absolute Oral Bioavailability of Traxoprodil in Cytochrome P450 2D6 Extensive and Poor Metabolisers
BackgroundTraxoprodil, a substituted 4-phenylpiperidine, is an N-methyl-D-aspartate (NMDA) receptor antagonist that is selective for receptors containing the NR2B subunit. In vivo and in vitroExpand
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Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.
High throughput screening (HTS) of our compound file provided an attractive lead compound with modest P2X(7) receptor antagonist potency and high selectivity against a panel of receptors andExpand
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