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The metabolic profile of azimilide in man: in vivo and in vitro evaluations.
- P. Riley, P. C. Figary, T. J. Moorehead
- Chemistry, BiologyJournal of pharmaceutical sciences
- 1 September 2005
The metabolic fate of azimilide in man is unusual as it undergoes a cleavage in vivo resulting in the formation of two classes of structurally distinct metabolites. During a metabolite profiling…
Effects of etidronate and lovastatin on the regression of atherosclerosis in cholesterol-fed rabbits.
It is suggested that etidronate with lovastatin can regress aortic atherosclerosis in the cholesterol-fed rabbit placed on a normal diet.
Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase.
 4-Hydroxyphenylpyruvate dioxygenase from pig liver
Interaction of azimilide with neurohumoral and channel receptors.
4-Hydroxyphenylpyruvate dioxygenase from pig liver.
A comparison of the potency and specificity of the direct muscle relaxant activity of azumolene and dantrolene
Dantrolene is a unique directly acting skeletal muscle relaxant that is clinically useful in the treatment of chronic muscle spasticity and malignant hyperthermia. Azumolene is a new dantrolene‐like…
Gastric Toxicity and Prostaglandin Content in Rats Dosed with Two Chemically Similar, Nonsteroidal Anti-Inflammatory Agents
- R. Brooks, T. J. Moorehead, S. F. Pong
- Biology, MedicineProceedings of the Society for Experimental…
- 1 February 1993
Extraction of prostagiandins from the gastric mucosa of pylorus-ligated rats revealed that the safer F-1067 depleted prostaglandin 6-keto-F1α less and increased prostag landin E2 much more than did orpanoxin, suggesting a possible causality.
Use of acylphosphotriamidderivater and pharmaceutically acceptable salts and / or hydrates thereof for the manufacture of a medicament for altering the lipid content in the blood plasma of mammals