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Development and validation of a fluorescence technology for both primary and secondary screening of kinases that facilitates compound selectivity and site-specific inhibitor determination.
TLDR
The IQ Technology has been developed to serve as a homogeneous, universal detection platform for HTS of kinases and phosphatases and provides a universal method that can be used with any peptide sequence and is insensitive to high concentrations of ATP. Expand
IQ™ Technology: Development of a Universal, Homogeneous Method for High-Throughput Screening of Kinase and Phosphatase Activity
IQ™ Technology is a homogeneous, universal detection platform designed specifically for high-throughput screening of kinases and phosphatases. The technology has been tested in 96- to 384- toExpand
IQ®Technology: An Automated, High-Throughput Screening Assay for Kinase, Phosphatase, and Protease Targets
IQ® Technology, a homogeneous, universal-detection platform, originally designed for high-throughput screening (HTS) of kinases and phosphatases, has now been applied to protease screening.Expand
IQ™ Technology: Development of a Universal, Homogeneous Method for High-Throughput Screening of Kinase and Phosphatase Activity
IQ™ Technology is a homogeneous, universal detection platform designed specifically for high-throughput screening of kinases and phosphatases. The technology has been tested in 96- to 384- toExpand
Sheet 2 of 27 US 7432 , 070 B 2 PseudoSubStrate Myelin
(56) References Cited (75) Inventors: M. Dean Savage, Rockford, IL (US); Timothy Jon McCauley, Rockford, IL U.S. PATENT DOCUMENTS (US); Sherri Z. Millis, Madison, WI 5,514,382 A * 5/1996 SultenfussExpand