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Human apolipoprotein A-I and A-II metabolism.
The kinetics of the major apolipoproteins of plasma high density lipoproteins, apoA-I and apo-II, were examined in a total of 44 individual tracer studies in 22 normal male and female subjects to show consistency with the following concepts. Expand
The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins.
A detailed correlation of the amino acid sequence, conformation, and self association of A-I will add further insight into the molecular mechanisms involved in protein-protein and protein-lipid interactions. Expand
New micromethod for measuring cholesterol in plasma lipoprotein fractions.
A method is described for the reliable, fast, and relatively inexpensive fractionation of plasma lipoproteins and quantitation of their cholesterol content and demonstrated the characteristic elevation of chylomicrons in phenotypes I and V, and continuum of pink color throughout the centrifuge tube. Expand
Metabolism of human apolipoproteins A-I and A-II: compartmental models.
The metabolism of radioiodinated apolipoproteins (apo) A-I and A-II has been examined using the techniques of compartmental modeling and findings are interpreted as indicating that apoA- I and apoB-II each have a separate metabolism which overlaps when they are present on the same lipoprotein particle. Expand
Pharmaceutical Drug Separations by HPCE: Practical Guidelines
Abstract As governmental regulations become more encompassing and restrictive, it has become more important to develop high efficiency separation methods for pharmaceutical drugs. High PerformanceExpand
Analysis of amino acid phenylthiohydantoins by gas chromatography.
A gas chromatographic procedure has been developed for the quantitative analysis of submicrogram amounts of the phenylthiohydantoins of all the amino acids except arginine, divided into three groups according to their volatility and need for derivatization (trimethylsilylation). Expand
Advances in the gas chromatographic analysis of amino acid phenyl- and methylthiohydantoins.
A new blend of silicone stationary phases (CFC), which provides superior resolving power than hitherto obtained with single phases or earlier blends and use of a carrier gas helium, which is a superior carrier gas to the more commonly used nitrogen and argon. Expand
Use of chemical ionization mass spectrometry in analysis of amino acid phenylthiohydantoin derivatives formed during Edman degradation of proteins.
The technique employs chemical ionization mass spectrometry and permits rapid identification of all PTH derivatives and use in the Edman degradation of sperm whale myoglobin is described and compared to gas chromatography. Expand
Self-association of apo-C-I from the human high density lipoprotein complex.
The molecular properties of apo-C-I, isolated from the human high density lipoprotein complex, have been evaluated as a function of pH, solvent composition, and protein concentration by sedimentationExpand
Human fibrinogen heterogeneities. II. Cross-linking capacity of high solubility catabolic intermediates.
Since polyacrylamide gel electrophoresis in sodium dodecyl sulfate showed that cross-linking of the γ chains was complete, it was concluded that the Aα chains of high solubility fibrinogens lack an average of two to three cross- linking sites. Expand