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Agelasines O–U, new diterpene alkaloids with a 9-N-methyladenine unit from a marine sponge Agelas sp.
Abstract New diterpene alkaloids, agelasines O–U (1–7), have been isolated from an Okinawan marine sponge Agelas sp. The gloss structures and relative stereochemistries of 1–7 were elucidated fromExpand
A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-Scale NMR-Coupled Crystalline Sponge X-ray Diffraction Analysis.
This study showcases a workflow integrating multiomics approaches, synthetic biology, and the crystalline sponge method, which is generally applicable for uncovering new terpene chemistry and biochemistry from source-limited living organisms. Expand
Crystalline-Sponge-Based Structural Analysis of Crude Natural Product Extracts.
A new CS-based workflow that greatly expedites the in-depth structural analysis of crude natural product extracts and demonstrates a new chemotyping workflow that can greatly accelerate natural product discovery from complex samples. Expand
Absolute configuration of amphidinin A.
The absolute configurations at six stereogenic centers in amphidinin A were elucidated to be 2R, 4R, 6S, 9R 11R, and 12S by the combination of J-based configuration analysis, modified Mosher's method, and density-functional theory calculations. Expand
Nagelamide I and 2,2'-didebromonagelamide B, new dimeric bromopyrrole-imidazole alkaloids from a marine sponge Agelas sp.
Two new dimeric bromopyrrole-imidazole alkaloids have been isolated from an Okinawan marine sponge Agelas species and the structures of 1 and 2 were elucidated based on analyses of the spectral data. Expand
Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp.
Four new polyketides, amphidinins C-F (1-4), have been isolated from the culture broth of symbiotic dinoflagellate Amphidinium sp. The analysis of their spectral data revealed that amphidinins C-FExpand
Amphidinin G, a putative biosynthetic precursor of amphidinin A from marine dinoflagellate Amphidinium sp.
A new linear polyketide, amphidinin G (1), has been isolated from a symbiotic marine dinoflagellate Amphidinium sp. The planar structure of 1 was established mainly based on the 2D NMR data and theExpand
Biosynthetic Study of Amphidinin A and Amphidinolide P.
The biogenetic origins of amphidinin A and Amphidinolide P were investigated by feeding experiments with (13)C-labeled acetates and revealed that the all carbons of 1 and 2 were derived from acetates. Expand