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Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
TLDR
Results clearly indicate that the pathogenic WNK4 mutant possesses a gain-of-function activity and that the claudins may be important molecular targets of WNK2 kinase, and the increased paracellular "chloride shunt" caused by the mutant W NK4 could be the pathogen mechanism of PHAII. Expand
Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.
TLDR
The selective localization of AQP12 in pancreatic acinar cells and possibly in the intracellular organelles suggests a role of AQp12 in digestive enzyme secretion such as maturation and exocytosis of secretory granules. Expand
MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5
TLDR
It is observed for the first time that miR-141 and -200a are involved in pre-osteoblast differentiation in part by regulating the expression of Dlx5. Expand
Intracellular localization of ClC chloride channels and their ability to form hetero‐oligomers
TLDR
Results suggest that within cells ClC‐3, Cl‐4, and Cl‐5 may have combinatorial functions, whereas ClC-6 and ClC•7 are more likely to function as homo‐oligomers. Expand
Genomic Structure and Promoter Analysis of the Bovine Leptin Gene
TLDR
The bovine leptin gene could be a potential candidate gene controlling some proportion of adipose and lean accretion in cattle, and thus, may be referred to as one of genetic factor controlling meat quality determinants such as marbling. Expand
Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages.
TLDR
Hydrogen inhibits LPS/IFNγ-induced NO production through modulation of signal transduction in macrophages and ameliorates inflammatory arthritis in mice, providing the molecular basis for hydrogen effects on inflammation and a functional interaction between two gaseous signaling molecules, NO and molecular hydrogen. Expand
Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.
TLDR
It is demonstrated that hydrogen attenuates phosphorylation of the FcepsilonRI-associated Lyn and its downstream signal transduction, which subsequently inhibits the NADPH oxidase activity and reduces the generation of hydrogen peroxide. Expand
Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
TLDR
It was found that alpha- or gamma-mangostin treatment was reduced the [Ca(2+)](i) elevation by suppressed Ca(2+) influx, suggesting that the inhibitory mechanism of xanthones was mainly due to suppression of the Syk/PLCgammas/PKC pathway. Expand
Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.
TLDR
It is suggested that preconditioning by sesquiterpene lactone may enhance activation of the Nrf2/ARE pathway and induction of phase II detoxification/antioxidant enzymes upon oxidative stress, thereby resulting in increased resistance to oxidative damage. Expand
Expression of BMP‐2 and Ets1 in BMP‐2‐stimulated mouse pre‐osteoblast differentiation is regulated by microRNA‐370
TLDR
It is found that miR‐370 regulates the expression of bone morphogenetic protein‐2 (BMP‐2) and V‐ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Ets1) in B MP‐2‐stimulated murine pre‐osteoblast MC3T3‐E1 cell differentiation. Expand
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