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Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
Mutations in the WNK4 gene cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder of hyperkalemia and hypertension. The target molecules of this putative kinase and theExpand
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Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.
Members of the aquaporin (AQP) water channel family are widely distributed in various tissues and contribute to the water permeability of epithelial and endothelial cells. Currently 11 members of theExpand
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Intracellular localization of ClC chloride channels and their ability to form hetero‐oligomers
ClC chloride channels (ClCs) can be classified into two groups in terms of their cellular localizations: ClCs present in the plasma membranes and those residing in intracellular organelles. MembersExpand
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MicroRNA-141 and -200a Are Involved in Bone Morphogenetic Protein-2-induced Mouse Pre-osteoblast Differentiation by Targeting Distal-less Homeobox 5
MicroRNAs (miRs) are endogenously expressed 18–25-nucleotide RNAs that regulate gene expression through translational repression by binding to a target mRNA. Recently, it was indicated that miRs actExpand
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Genomic Structure and Promoter Analysis of the Bovine Leptin Gene
The product of the leptin gene is a 16‐kDa protein secreted by adipose tissue and regulates adiposity. The leptin gene could be a potential candidate gene controlling some proportion of adipose andExpand
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Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages.
Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated thatExpand
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Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages.
  • Y. Akao, A. Iio, +4 authors T. Naoe
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 1 February 2011
Microvesicles (MVs) and exosomes, which are shed from cells as a cell-to-cell communication tool, are possible vehicles for navigating RNA molecules to body tissues. It is considered that intravenousExpand
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Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.
Molecular hydrogen ameliorates oxidative stress-associated diseases in animal models. We found that oral intake of hydrogen-rich water abolishes an immediate-type allergic reaction in mice. Using ratExpand
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Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.
  • Eriko Ohta, T. Itoh, +10 authors T. Rai
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • 1 December 2009
Aquaporin 12 (AQP12) is the most recently identified member of the mammalian AQP family and is specifically expressed in pancreatic acinar cells. In vitro expression studies have revealed that AQP12Expand
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Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
Mangostin, Garcinia mangostana L. is used as a traditional medicine in southeast Asia for inflammatory and septic ailments. Hitherto we indicated the anticancer activity induced by xanthones such asExpand
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