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Regulation of myeloid leukemia by the cell fate determinant Musashi
Chronic myelogenous leukaemia (CML) can progress from a slow growing chronic phase to an aggressive blast crisis phase, but the molecular basis of this transition remains poorly understood. Here we… Expand
Efficacy and adverse events of EMR and endoscopic submucosal dissection for the treatment of colon neoplasms: a meta-analysis of studies comparing EMR and endoscopic submucosal dissection.
BACKGROUND EMR and endoscopic submucosal dissection (ESD) are used frequently to remove colon neoplasms. However, the predominance of these procedures has not yet been thoroughly explored. … Expand
L1 drives IFN in senescent cells and promotes age-associated inflammation
Retrotransposable elements are deleterious at many levels, and the failure of host surveillance systems for these elements can thus have negative consequences. However, the contribution of… Expand
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia
Cell fate can be controlled through asymmetric division and segregation of protein determinants, but the regulation of this process in the hematopoietic system is poorly understood. Here we show that… Expand
Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.
- Jiandong Yu, Archana Proddutur, F. Elgammal, T. Ito, V. Santhakumar
- Chemistry, Medicine
- Journal of neurophysiology
- 1 April 2013
Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether… Expand
Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23.
- E. Imel, X. Zhang, +10 authors T. Carpenter
- The Journal of clinical endocrinology and…
- 28 April 2015
CONTEXT In X-linked hypophosphatemia (XLH), elevated fibroblast growth factor 23 (FGF23) decreases the renal tubular maximum reabsorption rate of phosphate/glomerular filtration rate (TmP/GFR) and… Expand
Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.
- M. Fosbrink, C. Cudrici, +6 authors H. Rus
- Biology, Medicine
- Experimental and molecular pathology
- 1 April 2009
Proliferation of vascular endothelial cells (EC) and smooth muscle cells (SMC) is a critical event in angiogenesis and atherosclerosis. We previously showed that the C5b-9 assembly during complement… Expand
Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1beta and TNF-alpha.
Fibroblast migration, proliferation, extracellular matrix protein synthesis and degradation, all of which play important roles in inflammation, are themselves induced by various growth factors and… Expand
Role of response gene to complement 32 in diseases
- S. Vlaicu, C. Cudrici, +5 authors H. Rus
- Biology, Medicine
- Archivum Immunologiae et Therapiae Experimentalis
- 31 March 2008
The role of response gene to complement (RGC)-32 as a cell cycle regulator has been attributed to its ability to activate cdc2 kinases and to induce S-phase entry and mitosis. However, recent studies… Expand
Pharmacokinetics and pharmacodynamics of a human monoclonal anti‐FGF23 antibody (KRN23) in the first multiple ascending‐dose trial treating adults with X‐linked hypophosphatemia
In X‐linked hypophosphatemia (XLH), serum fibroblast growth factor 23 (FGF23) is increased and results in reduced renal maximum threshold for phosphate reabsorption (TmP), reduced serum inorganic… Expand