T. Ito

Publications116
h-index30
Citations2,840
Highly Influential Citations74
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Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines.
We examined the in vitro effects of the benzophenone derivatives garcinol, isogarcinol, and xanthochymol on cell growth in four human leukemia cell lines. All of the compounds exhibited significant… Expand
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Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.
Our previous study has shown that alpha-mangostin, a xanthone from the pericarps of mangosteen, induces caspase-3-dependent apoptosis in HL60 cells. In the current study, we investigated the… Expand
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Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth… Expand
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Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum stress and inflammation.
Enhanced endoplasmic reticulum (ER) stress has been implicated in various pathological situations including inflammation. During a search for compounds that regulate ER stress, we identified… Expand
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Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
BackgroundAppropriate long-term drinking of red wine is associated with a reduced risk of cardiovascular disease. Resveratrol, a well-known SIRT1 activator is considered to be one of the beneficial… Expand
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Novel quinolinone alkaloids bearing a lignoid moiety and related constituents in the leaves of Melicope denhamii
Abstract Six novel quinolinone alkaloids bearing a phenylpropanoid or a coumarin moiety, named melicodenines C–H (1–6), two new cinnamyl alcohol derivatives, named melicodins A (7) and B (8), and a… Expand
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Stilbenoids isolated from stem bark of Shorea hemsleyana.
Two new stilbene glucosides [(+)-alpha-viniferin 13b-O-beta-glucopyranoside and resveratrol 12-C-beta-glucopyranoside] and two new resveratrol oligomers, hemsleyanols A and B, were isolated from the… Expand
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Dimeric chalcone derivatives from Mallotus philippensis
Two new chalcone derivatives with a unique ring system caused by dimerization between a dimethylchromene ring and a phenoxyl group, were isolated from kamala (Mallotus philippensis). The structures… Expand
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Novel, Complex Flavonoids from Mallotus philippensis (Kamala Tree)
One new flavanone, 4′-hydroxyisorottlerin (2), and two new chalcone derivatives, kamalachalcones C (3) and D (4), were isolated from Mallotus philippensis (kamala tree). The largest compound (4; Mr… Expand
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Absolute Configuration of Resveratrol Oligomers Isolated from Hopea utilis
Phytochemical studies on a stem of Hopea utilis (Dipterocarpaceae) resulted in the isolation of two new resveratrol derivatives, namely hopeaside E (1; resveratrol trimer) and hopeaside F (2;… Expand
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