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Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines.
- Kenji Matsumoto, Y. Akao, +5 authors Y. Nozawa
- Medicine, Chemistry
- Biological & pharmaceutical bulletin
- 1 April 2003
We examined the in vitro effects of the benzophenone derivatives garcinol, isogarcinol, and xanthochymol on cell growth in four human leukemia cell lines. All of the compounds exhibited significant… Expand
Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.
- K. Matsumoto, Y. Akao, +6 authors Y. Nozawa
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 November 2004
Our previous study has shown that alpha-mangostin, a xanthone from the pericarps of mangosteen, induces caspase-3-dependent apoptosis in HL60 cells. In the current study, we investigated the… Expand
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth… Expand
Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum stress and inflammation.
- Yoshiyuki Tabata, K. Takano, +6 authors O. Hori
- Biology, Medicine
- American journal of physiology. Cell physiology
- 1 July 2007
Enhanced endoplasmic reticulum (ER) stress has been implicated in various pathological situations including inflammation. During a search for compounds that regulate ER stress, we identified… Expand
Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
BackgroundAppropriate long-term drinking of red wine is associated with a reduced risk of cardiovascular disease. Resveratrol, a well-known SIRT1 activator is considered to be one of the beneficial… Expand
Novel quinolinone alkaloids bearing a lignoid moiety and related constituents in the leaves of Melicope denhamii
Abstract Six novel quinolinone alkaloids bearing a phenylpropanoid or a coumarin moiety, named melicodenines C–H (1–6), two new cinnamyl alcohol derivatives, named melicodins A (7) and B (8), and a… Expand
Stilbenoids isolated from stem bark of Shorea hemsleyana.
- T. Ito, T. Tanaka, Y. Ido, K. Nakaya, Munekazu Iinuma, S. Riswan
- Medicine, Chemistry
- Chemical & pharmaceutical bulletin
- 1 July 2000
Two new stilbene glucosides [(+)-alpha-viniferin 13b-O-beta-glucopyranoside and resveratrol 12-C-beta-glucopyranoside] and two new resveratrol oligomers, hemsleyanols A and B, were isolated from the… Expand
Dimeric chalcone derivatives from Mallotus philippensis
Two new chalcone derivatives with a unique ring system caused by dimerization between a dimethylchromene ring and a phenoxyl group, were isolated from kamala (Mallotus philippensis). The structures… Expand
Novel, Complex Flavonoids from Mallotus philippensis (Kamala Tree)
One new flavanone, 4′-hydroxyisorottlerin (2), and two new chalcone derivatives, kamalachalcones C (3) and D (4), were isolated from Mallotus philippensis (kamala tree). The largest compound (4; Mr… Expand
Absolute Configuration of Resveratrol Oligomers Isolated from Hopea utilis
Phytochemical studies on a stem of Hopea utilis (Dipterocarpaceae) resulted in the isolation of two new resveratrol derivatives, namely hopeaside E (1; resveratrol trimer) and hopeaside F (2;… Expand