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Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease.
- E. Koeck, T. Iordanskaia, +4 authors E. Nadler
- Biology, MedicineThe Journal of surgical research
- 1 December 2014
Exosomes from VAT integrate into liver cells and induce dysregulation of TGF-β pathway members in vitro and offers an intriguing possibility for the pathogenesis of NAFLD.
Mechanisms of transforming growth factor β induced cell cycle arrest in palate development
TGFβ1 and TGFβ3 play separate yet complimentary roles in achieving cell cycle arrest and EMT/apoptosis and cell cycle Arrest is a prerequisite for later cellular changes.
Dysregulation of upstream and downstream transforming growth factor-β transcripts in livers of children with biliary atresia and fibrogenic gene signatures.
- T. Iordanskaia, M. Hubal, E. Koeck, C. Rossi, K. Schwarz, E. Nadler
- Biology, MedicineJournal of pediatric surgery
- 1 October 2013
Gene transcripts for known upstream and downstream TGF-β mediators are differentially expressed in liver specimens from children with BA and a fibrogenic gene signature, and further investigation into whether these mediators may be attractive targets for future therapy inChildren with BA is warranted.
PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner
The results show that ROS are essential for PAC1 to regulate EGFR and HER2 transactivation as well as proliferation of NSCLC cells.
Integrin &bgr;-8, But Not &bgr;-5 or -6, Protein Expression Is Increased in Livers of Children With Biliary Atresia
- T. Iordanskaia, E. Koeck, +4 authors E. Nadler
- MedicineJournal of pediatric gastroenterology and…
- 1 December 2014
Analysis of liver fibrosis and protein expression of the integrins in a larger cohort of patients with BA and compared them with patients undergoing liver biopsy for other diagnoses support the mounting evidence that transforming growth factor-&bgr; (TGF-& bgr;) activation is responsible for the fibrosis found in BA.
Targeting Extracellular Cyclophilins Ameliorates Disease Progression in Experimental Biliary Atresia
- T. Iordanskaia, M. Malešević, G. Fischer, T. Pushkarsky, M. Bukrinsky, E. Nadler
- MedicineMolecular medicine
- 24 July 2015
The data provide the first evidence that extracellular cyclophilins activate the SMAD pathway and promote inflammation in experimental BA, and suggest that MM284 may be a promising therapeutic agent for treating BA and possibly other intrahepatic chronic disorders.
Molecular basis for high affinity and selectivity of peptide antagonist, Bantag-1, for the orphan BB3 receptor.
- Taichi Nakamura, I. Ramos-Álvarez, T. Iordanskaia, P. Moreno, S. Mantey, R. Jensen
- Chemistry, MedicineBiochemical pharmacology
- 1 September 2016
This study systematically investigated the molecular basis for changes demonstrated in EC1, particularly important is the presence of aromatic-interactions by His(107), rather than hydrogen-bonding or charge-charge interactions, for determining Bantag-1 high affinity/selectivity.
Presence of the P21-Activated Kinase, PAK4, in Pancreatic Acinar Cells and its Activation by Numerous Gastrointestinal Hormones and Growth Factors
Dysregulation of upstream and downstream TGF-beta transcripts in livers of children with biliary atr
[A model of the depressive syndrome in rats induced by the neurotoxin MPTP and autoantibodies to serotonin and dopamine].
- L. Vetrilé, N. Krupina, +4 authors T. Iordanskaia
- MedicineZhurnal vysshei nervnoi deiatelnosti imeni I P…
- 1 July 1997
It is suggested that disturbances in neuroimmune interactions play an important part in development of depressive states.