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Total synthesis of ecteinascidin 743.
A straightforward synthesis of ecteinascidin 743 was accomplished from readily available l-glutamic acid as a single chiral source. Our novel synthesis features a concise and convergent approach for
Total synthesis of ecteinascidin 743.
TLDR
This novel synthesis features a concise and convergent approach for construction of the B-ring, consisting of a sequence involving a stereoselective Heck reaction between a diazonium salt and an enamide, oxidative cleavage of the resulting alkene, and intramolecular ortho substitution of the phenol by an aldehyde.
Cyanoesterification of 1,2-dienes catalyzed by nickel.
TLDR
Cyanoformate esters add across 1,2-dienes in the presence of a nickel/PMe(2)Ph catalyst to afford beta-cyano-alpha-methylenealkanoates regioselectively to afford highly substituted acrylonitrile derivatives at high temperature under the nickel catalysis.
Conversion of Vindoline into 11-Mesyloxytabersonine.
Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.