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The in vivo pharmacological profile of CS‐747, a novel antiplatelet agent with platelet ADP receptor antagonist properties
- A. Sugidachi, F. Asai, T. Ogawa, T. Inoue, H. Koike
- British journal of pharmacology
- 1 April 2000
In vivo pharmacological profiles of CS‐747 show that it is an orally active and a potent antiplatelet and antithrombotic agent with a rapid onset and long duration of action, and warrants clinical evaluations of the agent. Expand
Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland.
- T. Inoue, M. Domae, K. Yamada, T. Furukawa
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 April 1996
The results suggest that OPC-14597 has a mixed agonist/antagonist profile at D2 receptors on lactotroph cells and thereby exerts either an antagonistic or an agonistic action, depending on the preexisting tone of the dopaminergic neuronal activities. Expand
Involvement of hypothalamic growth hormone (GH)-releasing factor in GH secretion induced by intracerebroventricular injection of somatostatin in rats.
- Y. Murakami, Y. Kato, Y. Kabayama, T. Inoue, H. Koshiyama, H. Imura
- Biology, Medicine
The results suggest that the central stimulating effect of SRIF-14 on rat GH secretion is mediated, at least in part, by hypothalamic GRF and not due to a direct action on the pituitary. Expand
Nitric oxide mediates interleukin-1-induced prostaglandin E2 production by vascular smooth muscle cells.
- T. Inoue, K. Fukuo, S. Morimoto, E. Koh, T. Ogihara
- Biology, Medicine
- Biochemical and biophysical research…
- 15 July 1993
It is suggested that NO at least in part mediates the IL-1-induced PGE2 production, and that NO may be one of the important signals for the activation of cyclooxygenase to produce P GE2 in VSMC. Expand
1,25-Dihydroxyvitamin D3 stimulates 45Ca2+-uptake by cultured vascular smooth muscle cells derived from rat aorta.
Effect of the sterol on cellular uptake of calcium and the effect of 1,25-dihydroxyvitamin D3 was abolished by cycloheximide (10(-5) M), a protein synthesis inhibitor clearly suggest that 1, 25- dihydroxv vitamin D3 may directly regulate cellular calcium homeostasis in vascular smooth muscle cells presumably via receptor mediated mechanism. Expand
Strong antiproliferative effects of baicalein in cultured rat hepatic stellate cells.
The strong antiproliferative effect of baicalein in hepatic stellate cells is demonstrated, showing the possibility of baicalsein as an antifibrogenetic drug for hepatic fibrosis. Expand
Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog.
The present findings that NPY evokes ACTH secretion and potentiates the effectiveness of CRF as a secretagogue, together with high concentrations of NPY in the hypothalamus and pituitary portal blood, suggest thatNPY is involved in the multihormonal control of ACTH release. Expand
The effect of topical CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure and aqueous humor dynamics in rabbits
Topical CS-088 can decrease IOP in rabbits and in the study on aqueous humor dynamics, a slight increase in USF (17%) was seen after a topical application ofCS-088 whereas changes in aQueous inflow or outflow facility were not observed. Expand
Effect of MS-153 on the development of behavioral sensitization to locomotion- and ataxia-inducing effects of phencyclidine
It is suggested that the attenuation of glutamatergic neural transmission enhances acute effects of PCP, in contrast, blocks the behavioral sensitization developed by repeated PCP treatment. Expand
Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614.
- T. Sawada, S. Hashimoto, +7 authors K. Yamamoto
- Chemistry, Medicine
- 1 September 2000
T614 and phenylmethyl sulfonyl fluoride (PMSF), a serine protease inhibitor, inhibited Leu-OME mediated killing of THP-1 cells, suggesting that T614 and other mNSAIDs may act as lysosomal protease inhibitors. Expand