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Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.
We have previously cloned a rabbit cDNA clone (OC-2) from an osteoclast cDNA library by the differential screening. OC-2 was found to encode a novel cysteine proteinase, tentatively called cathepsinExpand
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Conformational studies on the specific cleavage site of Type I collagen (alpha-1) fragment (157-192) by cathepsins K and L by proton NMR spectroscopy.
Cathepsins K and L are cysteine proteinases which are considered to play an important role in bone resorption. Type I collagen is the most abundant component of the extracellular matrix of bone andExpand
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Cathepsin K Antisense Oligodeoxynucleotide Inhibits Osteoclastic Bone Resorption*
Cathepsin K is a recently identified cysteine protease which is abundantly and selectively expressed in osteoclasts. To evaluate the contribution of cathepsin K to bone resorption processes, weExpand
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In vitro amidation for the preparation of an α-amidated peptide: enzymatic coupling with prolyl endopeptidase
By enzymatic coupling with an endopeptidase specific for proline residue, i.e., prolyl endopeptidase, an α-amidated peptide (LH-RH) has been prepared from its acid form precursor without anyExpand
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Affinity of single- or double-stranded oligodeoxyribonucleotides containing a thymine photodimer for T4 endonuclease V.
A gene for T4 endonuclease V was constructed by joining chemically synthesized oligodeoxyribonucleotides and expressed efficiently in Escherichia coli under the control of the E. coli tryptophanExpand
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Abstract #1244: Monotherapeutic and combination antitumor activities of TAK-701, a humanized anti-hepatocyte growth factor neutralizing antibody, against multiple types of cancer
Signaling of the hepatocyte growth factor (HGF)/c-Met pathway is strongly implicated in cancer progression and represents an important target for cancer treatment. TAK-701, a humanized anti-human HGFExpand
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Development of a simple and robust assay to screen for inhibitors of sphingosine kinases.
Sphingosine kinases (SPHKs) catalyze the formation of the bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), which plays important roles in a wide variety of intra- and extracellularExpand
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1, 3-DIPOLAR CYCLOADDITION LEADING TO N-ALKYLPYRROLIDINES
1, 3-Dipolar cycloaddition of an intermediary methyleneiminium ylide formed from N-(benzylidene) trimethylsilylmethylamine and alkyl halide to conjugated olefinic dipolarophiles has been found toExpand
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Prolilendopeptidasas expression vector for Flavobacterium meningosepticum.
A recombinant expression vector comprising a DNA sequence encoding prolylendopeptidase from Flavobacterium meningosepticum as shown in SEQ ID NO: 1 which extends from nucleotide position 317 to 2374Expand