T. Ikizler

Publications442
h-index84
Citations35,617
Highly Influential Citations781
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A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease.
TLDR
An expert panel to review and develop standard terminologies and definitions related to wasting, cachexia, malnutrition, and inflammation in CKD and AKI recommends the term 'protein-energy wasting' for loss of body protein mass and fuel reserves. Expand
The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia.
TLDR
The hypothesis that increased oxidative stress and its sequalae is a major contributor to increased atherosclerosis and cardiovascular morbidity and mortality found in uremia is proposed and it is proposed that retained uremic solutes such as beta-2 microglobulin, advanced glycosylated end products, cysteine, and homocysteine further contribute to the pro-atherogenic milieu of Uremia. Expand
Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences.
TLDR
Because MICS leads to a low body mass index, hypocholesterolemia, hypocreatininemia, and hypohomocysteinemia, a "reverse epidemiology" of cardiovascular risks can occur in dialysis patients, obesity, hypercholesterolesmia, and increased blood levels of creatinine and homocysteine appear to be protective and paradoxically associated with a better outcome. Expand
Spectrum of acute renal failure in the intensive care unit: the PICARD experience.
TLDR
There is a changing spectrum of ARF in the critically ill, characterized by a large burden of comorbid disease and extensive extrarenal complications, obligating the need for dialysis in the majority of patients. Expand
The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies.
TLDR
In the absence of diagnostic increases in serum creatinine, NGAL detects patients with likely subclinical AKI who have an increased risk of adverse outcomes and the concept and definition of AKI might need re-assessment. Expand
Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease.
TLDR
Evidence of increased oxidative stress and acute-phase inflammation in patients with stage 3-5 chronic kidney disease compared to healthy subjects that does not closely correlate with estimates of GFR is found. Expand
Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM).
TLDR
This consensus statement of current knowledge on the etiology of PEW syndrome in CKD is provided to increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of Pew. Expand
Timing of initiation of dialysis in critically ill patients with acute kidney injury.
TLDR
Among critically ill patients with AKI, initiation of dialysis at higher BUN concentrations was associated with an increased risk for death, and these results provide a rationale for prospective testing of alternative dialysis initiation strategies in critically ill Patients with severe AKI. Expand
Association between physical performance and all-cause mortality in CKD.
In older adults, measurements of physical performance assess physical function and associate with mortality and disability. Muscle wasting and diminished physical performance often accompany CKD,… Expand
Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
TLDR
In critically-ill patients, the dilution of sCr by fluid accumulation may lead to underestimation of the severity of AKI and increases the time required to identify a 50% relative increase in sCr. Expand
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