• Publications
  • Influence
The Pathogenesis of Rift Valley Fever
The pathology of RVF in human patients and several animal models is described, and the role of viral virulence factors and host factors that affect RVFV pathogenesis are summarized. Expand
Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation
expression of nsp1, the most N-terminal gene 1 protein, prevented Sendai virus-induced endogenous IFN-β mRNA accumulation without inhibiting dimerization of IFN regulatory factor 3, a protein that is essential for activation of theIFN- β promoter. Expand
Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells
It is demonstrated that SARS-CoV nsp1 suppressed host innate immune functions, including type I IFN expression, in infected cells and suggested that Sars- CoV nSp1 most probably plays a critical role in SARS -CoV virulence. Expand
Rescue of Infectious Rift Valley Fever Virus Entirely from cDNA, Analysis of Virus Lacking the NSs Gene, and Expression of a Foreign Gene
A T7 RNA polymerase-driven reverse genetics system is established to rescue infectious clones of RVFV MP-12 strain entirely from cDNA, the first for any phlebovirus, and represents the first demonstration of foreign gene expression in any bunyavirus. Expand
Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α Phosphorylation
The two distinct functions of the NSs, i.e., the suppression of host transcription, including that of type I interferon mRNAs, and the downregulation of PKR, work together to prevent host innate antiviral functions, allowing efficient replication and survival of RVFV in infected mammalian hosts. Expand
Rift valley fever vaccines.
This article summarizes the development of inactivated RVFV vaccine, live attenuated vaccine, and other new generation vaccines. Expand
Molecular biology and genetic diversity of Rift Valley fever virus.
  • T. Ikegami
  • Biology, Medicine
  • Antiviral research
  • 1 September 2012
High degree of conservation of genes encoding the virion surface glycoproteins suggests that a single vaccine should protect against all currently circulating RVFV strains, and preservation of the sequence of the RNA-dependent RNA polymerase across viral lineages implies that antiviral drugs targeting the enzyme should be effective against all strains. Expand
Reston Ebolavirus Antibodies in Bats, the Philippines
The prevalence of REBOV antibody–positive bats in the Philippines is determined and rabbit anti-bat IgG and horseradish peroxidase–conjugated anti-rabbit IgG strongly cross-reacts with IgGs of other bat species, including insectivorous bats. Expand
NSm Protein of Rift Valley Fever Virus Suppresses Virus-Induced Apoptosis
RVFV NSm protein is the first identified Phlebovirus protein that has an antiapoptotic function, demonstrating that other viral proteins were dispensable for NSm's function in inhibiting apoptosis. Expand
Rift Valley Fever Virus Nonstructural Protein NSs Promotes Viral RNA Replication and Transcription in a Minigenome System
The finding that RVFV NSs protein augmented minigenome RNA synthesis was in sharp contrast to reports that Bunyamwera virus (genus Bunyavirus) NSsprotein inhibits viral minigenomes that originated from S and L RNA segments, suggesting that RVfVNSs protein and Buny AMV have distinctly different biological roles in viral RNA synthesis. Expand