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Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture. To gainExpand
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Transcriptional Regulatory Networks in Saccharomyces cerevisiae
We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as maps of metabolicExpand
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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent embryonic stem cells (ESCs). We reportExpand
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Polycomb complexes repress developmental regulators in murine embryonic stem cells
The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the ability to differentiate into virtually all adult cell types are not well understood. Polycomb group (PcG) proteinsExpand
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Super-Enhancers in the Control of Cell Identity and Disease
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biologyExpand
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Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2)Expand
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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells. Here, weExpand
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Remodeling of yeast genome expression in response to environmental changes.
We used genome-wide expression analysis to explore how gene expression in Saccharomyces cerevisiae is remodeled in response to various changes in extracellular environment, including changes inExpand
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Dissecting the Regulatory Circuitry of a Eukaryotic Genome
Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNAExpand
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Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast
Eukaryotic genomes are packaged into nucleosomes whose position and chemical modification state can profoundly influence regulation of gene expression. We profiled nucleosome modifications across theExpand
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