• Publications
  • Influence
Human skin wounds: A major and snowballing threat to public health and the economy
In the United States, chronic wounds affect 6.5 million patients. An estimated excess of US$25 billion is spent annually on treatment of chronic wounds and the burden is rapidly growing due toExpand
  • 1,659
  • 61
  • PDF
Effect of hyperoxia on vascular endothelial growth factor levels in a wound model.
HYPOTHESIS Hyperbaric oxygen (HBO) therapy increases vascular endothelial growth factor (VEGF) levels in wounds. DESIGN Wounds were monitored for oxygen delivery during HBO treatment, and woundExpand
  • 262
  • 12
  • PDF
Oxygen tension regulates the expression of angiogenesis factor by macrophages.
When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those ofExpand
  • 640
  • 10
  • PDF
Wound tissue oxygen tension predicts the risk of wound infection in surgical patients.
OBJECTIVE To test the hypothesis that subcutaneous wound oxygen tension (PsqO2) has a predictive relation to the development of wound infection in surgical patients. DESIGN A noninterventional,Expand
  • 413
  • 10
Dermal wound healing is subject to redox control.
Previously we have reported in vitro evidence suggesting that that H2O2 may support wound healing by inducing VEGF expression in human keratinocytes (C. K. Sen et al., 2002, J. Biol. Chem.277,Expand
  • 317
  • 10
Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms.
BACKGROUND "Respiratory burst" activity, ie, O2- production, is dependent on PO2, temperature, pH, and glucose concentrations within the physiologic range. OBJECTIVES To determine whetherExpand
  • 424
  • 9
Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration.
Tissue hypoxia is a well-known stimulus to angiogenesis. The central dead space in healing wounds has been shown to be hypoxic (PO2 = 1 to 10). Angiogenesis is a necessary component of all healingExpand
  • 616
  • 8
Impaired wound contraction in stromelysin-1-deficient mice.
OBJECTIVE To determine whether the deletion of stromelysin-1, a single metalloproteinase gene product, will alter the time course and quality of dermal wound repair in mice. SUMMARY BACKGROUND DATAExpand
  • 220
  • 8
Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites
Relaxin is a reproductive hormone that has historically been characterized as being responsible for pubic ligament loosening and cervical ripening. Recently, relaxin has been associated withExpand
  • 140
  • 8
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms.
Hypoxia serves as a physiologic cue to drive an angiogenic response via HIF-dependent mechanisms. Interestingly, minor elevation of lactate levels in the tissue produces the same effect under aerobicExpand
  • 158
  • 8