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A Randomized, Double-Blind, Placebo-Controlled Study of the Effect of Sustained-Release Bupropion on Blood Pressure in Individuals With Mild Untreated Hypertension
The effects of bupropion on blood pressure and heart rate were evaluated in a double-blind, placebo-controlled study of community volunteers with untreated mild (stage 1) hypertension (systolic bloodExpand
Effects of wheat bran and olestra on objective measures of stool and subjective reports of GI symptoms
OBJECTIVE:The aim of this study was to compare the effects of two nondigested, nonabsorbed dietary components on objective and subjective measures of gastrointestinal (GI) function.METHODS:AExpand
ENaC inhibitors for the treatment of cystic fibrosis.
The epithelial Na(+) channel, ENaC, is a key regulator of the volume of airway surface liquid in the human airway epithelium. In cystic fibrosis (CF), Na(+) hyperabsorption through ENaC in theExpand
Effect of Rofecoxib on the Pharmacokinetics of Chronically Administered Oral Contraceptives in Healthy Female Volunteers
The effect of rofecoxib, a highly selective cyclooxygenase (COX)‐2 inhibitor, on the pharmacokinetics of ethinyl estradiol (EE) and norethindrone (NET), two common components of a combination oralExpand
Evaluation of the Abuse Potential of Pagoclone, a Partial GABAA Agonist
Abstract: This study assessed the abuse potential of pagoclone, a partial agonist at the &ggr;-aminobutyric acid type A (GABAA) benzodiazepine receptor site, in healthy recreational drug users.Expand