T. Horie

Publications124
h-index22
Citations3,171
Highly Influential Citations105
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Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage
TLDR
The results suggest that elevated levels of circulating miR-133a in patients with cardiovascular diseases originate mainly from the injured myocardium, and it may have functions in cardiovascular diseases.
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo
  • T. Horie, K. Ono, T. Kita
  • Biology
    Proceedings of the National Academy of Sciences
  • 20 September 2010
TLDR
A critical role is established for miR-33 in the regulation of ABCA1 expression and HDL biogenesis in vivo in mice lacking microRNA (miR)-33.
MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes.
Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet.
MicroRNA-33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE−/− Mice
TLDR
It is demonstrated that miR-33 deficiency serves to raise HDL-C, increase cholesterol efflux from macrophages via ABCA1 and ABCG1, and prevent the progression of atherosclerosis.
MicroRNA-15b Modulates Cellular ATP Levels and Degenerates Mitochondria via Arl2 in Neonatal Rat Cardiac Myocytes*
TLDR
The present results suggest that miR-15b may decrease mitochondrial integrity by targeting Arl2 in the heart and down-regulate the same target genes and consequently decrease cellular ATP levels.
Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway
TLDR
Findings suggested that the up-regulation of miR-146a after Dox treatment is involved in acute Dox-induced cardiotoxicity by targeting ErbB4.
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
TLDR
It is shown that deletion of miR-33 results in marked worsening of high-fat diet-induced obesity and liver steatosis and a novel interaction between SRE BP-1 and SREBP-2 mediated by miR -33 in vivo is elucidated.
Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5.
TLDR
The regulation of adipocyte differentiation by 5-HT, 5- HT(2A)R, and5-HT(2C)R is identified and miR-448-mediated repression of KLF5 was identified as a negative regulator for adipocytes differentiation.
Distinct Characteristics of Circulating Vascular Endothelial Growth Factor-A and C Levels in Human Subjects
TLDR
It is demonstrated that V EGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis.
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