• Publications
  • Influence
Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: the bistramide C analysis.
[reaction: see text] The combination of NMR NOE, chemical shift, and J-coupling measurements with molar rotation and circular dichroism (CD) determinations, including RI-DFT BP86/aug-cc-pVDZExpand
  • 19
  • 1
Severe leukocytosis with neutrophilia (leukemoid reaction) in alcoholic steatohepatitis
colitis was unremarkable, and the patient did not appear to have predisposing factors for ischemic colitis. Although I agree with the cautious conclusion that Aeromonasmay have been responsible forExpand
  • 14
  • 1
Supportive and Palliative Care in Cancer.
  • 18
  • 1
Efficacy of imidacloprid for removal and control of fleas (Ctenocephalides felis) on dogs.
OBJECTIVE To evaluate efficacy of a 9.1% (w/w) imidacloprid solution, applied topically, to remove fleas from dogs and the duration of residual flea control when dogs were exposed to continuing fleaExpand
  • 42
New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead.
Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin-thioredoxin reductase redox system. The mostExpand
  • 35
Total synthesis and structure validation of (+)-bistramide C.
The convergent total synthesis of the marine natural product (+)-bistramide C confirms the a priori assignments of its relative and absolute configurations, which were originally based on theExpand
  • 37
  • PDF
Studies in Natural Product Chemistry: Synthesis of Palmarumycin CP1 Analogs and Total Synthesis and Structure Validation of (+)-Bistramide C
The first chapter describes our preparation of novel analogs of the natural product, palmarumycin CP1. Several derivatives demonstrated potent and selective inhibition of thioredoxin and thioredoxinExpand
  • 12
Tubulin‐Perturbing Naphthoquinone Spiroketals
Several natural and synthetic naphthoquinone spiroketals are potent inhibitors of the thioredoxin–thioredoxin reductase redox system. Based on the antimitotic and weak antitubulin actions noted forExpand
  • 4
Rituximab is an effective treatment in cutaneous histiocyte predominant T-cell rich B-cell lymphoma
6744 Rituximab, an anti CD-20 monoclonal antibody, is efficacious in multiple subtypes of systemic B-cell non-Hodgkin’s lymphoma. Its use in cutaneous B-cell non-Hodgkin’s lymphomas is limited. Its...