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Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: the bistramide C analysis.
- G. Zuber, M. Goldsmith, T. Hopkins, D. Beratan, P. Wipf
- Chemistry, Medicine
- Organic letters
- 15 October 2005
[reaction: see text] The combination of NMR NOE, chemical shift, and J-coupling measurements with molar rotation and circular dichroism (CD) determinations, including RI-DFT BP86/aug-cc-pVDZ… Expand
Severe leukocytosis with neutrophilia (leukemoid reaction) in alcoholic steatohepatitis
colitis was unremarkable, and the patient did not appear to have predisposing factors for ischemic colitis. Although I agree with the cautious conclusion that Aeromonasmay have been responsible for… Expand
New Inhibitors of the Thioredoxin—Thioredoxin Reductase System Based on a Naphthoquinone Spiroketal Natural Product Lead.
Efficacy of imidacloprid for removal and control of fleas (Ctenocephalides felis) on dogs.
- R. Arther, J. Cunningham, H. Dorn, R. Everett, L. G. Herr, T. Hopkins
- American journal of veterinary research
- 1 August 1997
OBJECTIVE To evaluate efficacy of a 9.1% (w/w) imidacloprid solution, applied topically, to remove fleas from dogs and the duration of residual flea control when dogs were exposed to continuing flea… Expand
New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead.
- P. Wipf, T. Hopkins, +5 authors G. Powis
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 8 October 2001
Natural products of the naphthoquinone spiroketal structural type served as lead structures for the development of novel inhibitors of the thioredoxin-thioredoxin reductase redox system. The most… Expand
Total synthesis and structure validation of (+)-bistramide C.
The convergent total synthesis of the marine natural product (+)-bistramide C confirms the a priori assignments of its relative and absolute configurations, which were originally based on the… Expand
Studies in Natural Product Chemistry: Synthesis of Palmarumycin CP1 Analogs and Total Synthesis and Structure Validation of (+)-Bistramide C
- T. Hopkins
- 4 October 2005
The first chapter describes our preparation of novel analogs of the natural product, palmarumycin CP1. Several derivatives demonstrated potent and selective inhibition of thioredoxin and thioredoxin… Expand
Tubulin‐Perturbing Naphthoquinone Spiroketals
- R. Balachandran, T. Hopkins, C. Thomas, P. Wipf, B. Day
- Biology, Medicine
- Chemical biology & drug design
- 1 February 2008
Several natural and synthetic naphthoquinone spiroketals are potent inhibitors of the thioredoxin–thioredoxin reductase redox system. Based on the antimitotic and weak antitubulin actions noted for… Expand
Rituximab is an effective treatment in cutaneous histiocyte predominant T-cell rich B-cell lymphoma
6744 Rituximab, an anti CD-20 monoclonal antibody, is efficacious in multiple subtypes of systemic B-cell non-Hodgkin’s lymphoma. Its use in cutaneous B-cell non-Hodgkin’s lymphomas is limited. Its...