• Publications
  • Influence
A simulation study of the number of events per variable in logistic regression analysis.
Findings indicate that low EPV can lead to major problems, and the regression coefficients were biased in both positive and negative directions, and paradoxical associations (significance in the wrong direction) were increased. Expand
A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study.
It is concluded that in patients with acute spinal-cord injury, treatment with methylprednisolone in the dose used in this study improves neurologic recovery when the medication is given in the first eight hours. Expand
A multicomponent intervention to prevent delirium in hospitalized older patients.
The intervention was associated with significant improvement in the degree of cognitive impairment among patients with cognitive impairment at admission and a reduction in the rate of use of sleep medications among all patients, suggesting that primary prevention of delirium is probably the most effective treatment strategy. Expand
The estimation of age, period and cohort effects for vital rates.
  • T. Holford
  • Mathematics, Medicine
  • Biometrics
  • 1 June 1983
In models for vital rates which include effects due to age, period and cohort, there is aliasing due to a linear dependence among these three factors both when age and period intervals are equal and when they are not. Expand
Understanding the effects of age, period, and cohort on incidence and mortality rates.
  • T. Holford
  • Psychology, Medicine
  • Annual review of public health
  • 1991
Time trends for population-based disease rates often are summarized by using direct adjustment by period of diagnosis or death, but these summaries only can adjust for the effect of age in a given period; they implicitly ignore the cohort effect. Expand
International patterns and trends in thyroid cancer incidence, 1973–2002
Analysis of published CI5 data suggests that thyroid cancer rates increased between 1973 and 2002 in most populations worldwide, and that the increase does not appear to be restricted to a particular region of the world or by the underlying rates of thyroid cancer. Expand
Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury: Results of the Third National Acute Spinal Cord Injury
Patients who received the 48-hour methylprednisolone regimen and who started treatment at 3 to 8 hours were more likely to improve 1 full neurologic grade and show improved motor recovery at 6 weeks and 6 months after injury. Expand
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Treatment with the study dose of methylprednisolone is indicated for acute spinal cord trauma, but only if it can be started within 8 hours of injury. Expand
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
Common polymorphisms in TNF and IL10, key cytokines for the inflammatory response and Th1/Th2 balance, could be susceptibility loci for non-Hodgkin lymphoma. Expand
Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates.
The analytical effect of the number of events per variable (EPV) in a proportional hazards regression analysis was evaluated using Monte Carlo simulation techniques for data from a randomized trialExpand