T. Hirokawa

Publications178
h-index25
Citations5,152
Highly Influential Citations310
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SOSUI: classification and secondary structure prediction system for membrane proteins
TLDR
UNLABELLED The system SOSUI for the discrimination of membrane proteins and soluble ones together with the prediction of transmembrane helices was developed, in which the accuracy of the classification of proteins was 99% and the corresponding value for the transmemBRane helix prediction was 97%. Expand
Ubiquitin is phosphorylated by PINK1 to activate parkin
PINK1 (PTEN induced putative kinase 1) and PARKIN (also known as PARK2) have been identified as the causal genes responsible for hereditary recessive early-onset Parkinsonism. PINK1 is a Ser/Thr… Expand
Structural Basis for a Broad But Selective Ligand Spectrum of a Mouse Olfactory Receptor: Mapping the Odorant-Binding Site
The olfactory receptor (OR) superfamily provides a basis for the remarkable ability to recognize and discriminate a large number of odorants. In mice, the superfamily includes ∼1000 members, and they… Expand
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
Intestinal cancer is one of the most common human cancers. Aberrant activation of the canonical Wnt signaling cascade, for example, caused by adenomatous polyposis coli (APC) gene mutations, leads to… Expand
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.
Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is a neuron-specific ubiquitin recycling enzyme. A mutation at residue 93 and polymorphism at residue 18 within human UCH-L1 are linked to familial… Expand
Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane-water interfaces
TLDR
MOTIVATION An amphiphilicity index of amino acid residues was developed for improving the method of transmembrane helix prediction. Expand
Analysis of multiple compound–protein interactions reveals novel bioactive molecules
The discovery of novel bioactive molecules advances our systems‐level understanding of biological processes and is crucial for innovation in drug development. For this purpose, the emerging field of… Expand
Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly.
Mitochondria import nearly all of their resident proteins from the cytosol, and the TOM complex functions as their entry gate. The TOM complex undergoes a dynamic conversion between the majority… Expand
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
BackgroundProneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75NTR) and Trk tyrosine kinase receptors, respectively; however the molecular roles of… Expand
Protein structure prediction using a variety of profile libraries and 3D verification
TLDR
This study is intended to construct a useful method for fold recognition, regardless of whether the proteins to be compared are evolutionarily related. Expand
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