T. Hirokawa

Publications193
h-index28
Citations5,881
Highly Influential Citations333
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SOSUI: classification and secondary structure prediction system for membrane proteins
UNLABELLED The system SOSUI for the discrimination of membrane proteins and soluble ones together with the prediction of transmembrane helices was developed, in which the accuracy of the…
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Ubiquitin is phosphorylated by PINK1 to activate parkin
TLDR
The results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full activation of parkin E3 activity, and demonstrate that phosphorylated ubiquit in is a parkin activator.
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Structural Basis for a Broad But Selective Ligand Spectrum of a Mouse Olfactory Receptor: Mapping the Odorant-Binding Site
TLDR
The current study reveals the molecular environment of the odorant-binding site, and it further advances the understanding of GPCR pharmacology.
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Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
TLDR
It is shown that the AhR E3 ubiquitin ligase has a role in suppression of intestinal carcinogenesis by a previously undescribed ligand-dependent β-catenin degradation pathway that is independent of and parallel to the APC system.
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Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.
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Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane-water interfaces
TLDR
The moving average of the amphiphilicity index actually showed significant peaks in the end regions of most transmembrane helices, indicating their preference for the membrane-water interface.
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Analysis of multiple compound–protein interactions reveals novel bioactive molecules
TLDR
It is demonstrated that machine learning of multiple CPIs can not only assess drug polypharmacology but can also efficiently identify novel bioactive scaffold‐hopping compounds that were not identified by existing computational ligand‐screening methods in comparative studies.
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Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
TLDR
Interestingly, in marked contrast to the action of matBDNF, CR-proBDNF dramatically reduced the number of cholinergic fibers and hippocampal dendritic spines, without affecting the survival of these neurons.
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Physicochemical factors for discriminating between soluble and membrane proteins: hydrophobicity of helical segments and protein length.
TLDR
The characteristics of MH helices, longer than 19 residues in length, in 97 membrane proteins whose three-dimensional structure or topology is known, as well as 397 soluble proteins selected from the Protein Data Bank, showed a characteristic relationship with the length of the protein.
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Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids*
TLDR
Using mixed species pairings of human and mouse sweet receptor subunits and chimeras, it is determined that the transmembrane domain of hT1R3 was mainly required for the sweet-suppressing effect of gymnemic acids.
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