ATP-sensitive K+ channel in the mitochondrial inner membrane
- I. Inoue, H. Nagase, Kuki Kishi, T. Higuti
- BiologyNature
- 18 July 1991
The results indicate that mitochondria depolarize by generating a K+ conductá-ance when ATP in the matrix is deficient.
Possible role of cell surface H+ -ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells.
- N. Arakaki, T. Nagao, T. Higuti
- Biology, ChemistryMolecular Cancer Research
- 1 November 2003
The present results demonstrate that the use of small molecular H(+)-ATP synthase inhibitors targeting the F(1) catalytic domain may lead to significant advances in potential antiangiogenic cancer therapies.
Alkyl Gallates, Intensifiers of β-Lactam Susceptibility in Methicillin-Resistant Staphylococcus aureus
- H. Shibata, K. Kondo, T. Higuti
- BiologyAntimicrobial Agents and Chemotherapy
- 1 February 2005
It is clearly demonstrates that the length of the alkyl chain has a key role in the elevation of susceptibility to β-lactam antibiotics.
Extraction and purification of effective antimicrobial constituents of Terminalia chebula RETS. against methicillin-resistant Staphylococcus aureus.
- Y. Sato, H. Oketani, T. Higuti
- BiologyBiological and Pharmaceutical Bulletin
- 15 April 1997
Examination of the EtOH extract of the fruiting bodies of Terminalia chebula RETZ. led to the isolation of two potent antimicrobial substances against even methicillin-resistant strains of…
Antibacterial and antioxidant activities of quercetin oxidation products from yellow onion (Allium cepa) skin.
- Freddy A. Ramos, Y. Takaishi, M. Takeuchi
- Chemistry, BiologyJournal of Agricultural and Food Chemistry
- 21 April 2006
Four new quercetin-derived oxidation products and lunularin-4-O-beta-D-glucoside were isolated from a water extract of onion (Allium cepa) skin, together with 17 other known compounds, and evaluation of antioxidant activity against DPPH showed that the new derivative compounds and 2,5,7,3',4'-pentahydroxy-3,4-flavandione are more active than quercets.
Coumarins and gamma-pyrone derivatives from Prangos pabularia: antibacterial activity and inhibition of cytokine release.
- Y. Tada, Y. Shikishima, Y. Ohmoto
- ChemistryPhytochemistry
- 1 March 2002
Cell‐surface H+‐ATP synthase as a potential molecular target for anti‐obesity drugs
- N. Arakaki, Toshiyuki Kita, H. Shibata, T. Higuti
- Biology, ChemistryFEBS Letters
- 24 July 2007
Antiviral effect of octyl gallate against DNA and RNA viruses.
- Misao Uozaki, H. Yamasaki, Yukiko Katsuyama, M. Higuchi, T. Higuti, A. H. Koyama
- Biology, ChemistryAntiviral Research
- 1 February 2007
Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus.
- Y. Sato, S. Suzaki, T. Nishikawa, M. Kihara, H. Shibata, T. Higuti
- BiologyJournal of Ethnopharmacology
- 1 October 2000
Triple Combinations of Lower and Longer Alkyl Gallates and Oxacillin Improve Antibiotic Synergy against Methicillin-Resistant Staphylococcus aureus
- H. Shibata, T. Nakano, T. Higuti
- BiologyAntimicrobial Agents and Chemotherapy
- 17 February 2009
Combinations of these gallates remarkably reduced oxacillin MICs against methicillin-resistant Staphylococcus aureus to below the antibiotic breakpoint (≤2 μg/ml).
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