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An Observational Trial for Papillary Thyroid Microcarcinoma in Japanese Patients
TLDR
Comparison of the outcomes of 340 patients with PMC who underwent observation and the prognosis of 1,055 patients who underwent immediate surgery without observation shows papillary microcarcinomas that are not associated with unfavorable features can be candidates for observation regardless of patient background and clinical features.
Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation.
TLDR
Although PTMC in young patients may be more progressive than in older patients, it might not be too late to perform surgery after subclinical PTMC has progressed to clinical disease, regardless of patient age.
BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients.
TLDR
There is no evidence that BRAF(V600E) mutation significantly reflects the aggressive characteristics and poor prognosis of patients with papillary carcinoma in Japan.
Prognosis of patients with papillary thyroid carcinoma having clinically apparent metastasis to the lateral compartment.
TLDR
It is suggested that N1b patients having metastasis larger than 3cm, those showing extranodal extension, and those having 5 or more clinically apparent metastasis should be regarded as high-risk, and that careful surgical treatment and postoperative follow-up are necessary.
Biological behavior and prognosis of familial papillary thyroid carcinoma.
TLDR
Although routine total thyroidectomy is recommended for familial papillary carcinoma, its therapeutic strategy can otherwise be the same as that for sporadic papilla carcinoma.
Prevalence and Prognostic Significance of Poor Differentiation and Tall Cell Variant in Papillary Carcinoma in Japan
TLDR
Although poorly differentiated carcinoma (Sakamoto) predicted the likelihood of carcinoma recurrence, it is more appropriate to define this lesion as one of the histological subtypes of papillary carcinoma rather than as an independent histological entity.
Incidences of Unfavorable Events in the Management of Low-Risk Papillary Microcarcinoma of the Thyroid by Active Surveillance Versus Immediate Surgery
TLDR
The oncological outcomes of the immediately surgery and active surveillance groups were similarly excellent, but the incidences of unfavorable events were definitely higher in the immediate surgery group, and active Surveillance is now recommended as the best choice for patients with low-risk PMC.
Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe
TLDR
Central node metastasis independently predicts a worse DFS for patients with papillary carcinoma larger than 1 cm, and the frequency was increased in relation to tumor size.
Prognostic impact of serum thyroglobulin doubling-time under thyrotropin suppression in patients with papillary thyroid carcinoma who underwent total thyroidectomy.
TLDR
Tg-DT (all data or first four data) is a very strong prognostic predictor superior to the classical prognostic factors in patients with PTC and was the only independent predictor of distant metastases and loco-regional recurrence on multivariate analysis.
Improvement in phonation after reconstruction of the recurrent laryngeal nerve in patients with thyroid cancer invading the nerve.
TLDR
In patients with thyroid cancer requiring RLN resection, RLN reconstruction achieved recovery in phonatory function and phonation efficiency index values at 1 year after operation was significantly greater than pre-operative PEI.
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