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Polycystic ovary syndrome
Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects about one in 15 women worldwide. The major endocrine disruption is excessive androgen secretion or activity, and a largeExpand
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The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome.
The human androgen receptor (AR) gene contains a polymorphic trinucleotide (CAG) repeat sequence in exon 1. The number of CAG repeats may confer differential receptor activity, and specific ranges ofExpand
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Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the ARExpand
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Regulators of genetic risk of breast cancer identified by integrative network analysis
Genetic risk for breast cancer is conferred by a combination of multiple variants of small effect. To better understand how risk loci might combine, we examined whether risk-associated genes shareExpand
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Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?
Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breastExpand
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Corrigendum: Progesterone receptor modulates ERα action in breast cancer
This corrects the article DOI: 10.1038/nature14583
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Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation
Oocytes regulate follicle growth by secreting paracrine growth factors that act on neighbouring granulosa cells (GCs). Those factors identified to date are mainly members of the transforming growthExpand
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Complexities of androgen receptor signalling in breast cancer.
While the clinical benefit of androgen-based therapeutics in breast cancer has been known since the 1940s, we have only recently begun to fully understand the mechanisms of androgen action in breastExpand
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Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome.
CONTEXT The cause of polycystic ovary syndrome (PCOS) is unknown, although genetic and environmental influences are clearly implicated. Some genetic studies have suggested the involvement of X-linkedExpand
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Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer
Individual and concerted actions of ER and PR highlight the prognostic and therapeutic value of PR in ER+/PR+ breast cancers. The functional role of progesterone receptor (PR) and its impact onExpand
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