T. Herrin

Publications30
h-index11
Citations401
Highly Influential Citations1
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Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS.
TLDR
The synthesis and broad-spectrum antiviral activity of two oxetanocin 11 analogues are reported, capable of controlling the replication of both HIV and herpesviruses.
Further developments in the nonenzymic biogenetic-like steroid synthesis.
Structure-activity studies on phosphonoacetate
TLDR
Results showed that the antiherpesvirus activity had highly specific structural requirements and neither the carboxylic nor the phosphono groups could be replaced, and some compounds with decreased activity in vitro appeared to have favorable pharmacological properties in vivo.
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
The design, synthesis, and molecular modeling studies of a novel series of azacyclic ureas, which are inhibitors of human immunodeficiency virus type 1 (HIV-1) protease that incorporate different…
Synthesis and anti-herpes simplex activity of analogues of phosphonoacetic acid.
TLDR
The synthesis of monoesters (P and C) of phosphonoacetic acid and three aryl- (alkyl-)phosphinic acid derivatives were evaluated for anti-herpes activity against HSV-induced DNA polymerase and in animals infected with herpes dermatitis.
Preparation of biologically active ristocetin derivatives: replacements of the 1'-amino group.
A series of ristocetin analogues with modifications (OH, C=O, C=NOH, NCOCH3) at the C-1' amino group was synthesized and found to possess antibacterial activity against gram-positive bacteria and to…
Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir).
ACYL TETRAMIC ACIDS. 6. SYNTHESIS OF 3-DIENOYL TETRAMIC ACIDS RELATED TO STREPTOLYDIGIN AND TIRANDAMYCIN
SYNTHESIS AND ANTI-HERPES SIMPLEX ACTIVITY OF ANALOGS OF PHOSPHONOACETIC ACID
Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea--synthesis and structure-activity relationships.
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