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Modified National Institutes of Health Stroke Scale for Use in Stroke Clinical Trials: Prospective Reliability and Validity
TLDR
A prospective study found high reliability and continued validity by using a previously developed mNIHSS, which showed improved agreement between examiners and was also easier to administer, having fewer and simpler items.
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Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study
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Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke (ICTuS-L): Final Results
TLDR
Pneumonia was more frequent after hypothermia, but further studies are needed to determine its effect on patient outcome and whether it can be prevented, and the feasibility and preliminary safety of combining endovascular Hypothermia after stroke with intravenous thrombolysis.
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A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology.
TLDR
This is a method by which a rapid and precise therapeutic decrease in core temperature can be achieved without the necessity for intubation or neuromuscular blockade and with minimal patient discomfort or shivering.
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Induced Hypothermia for Acute Stroke
TLDR
This review elaborates on the clinical implications of hypothermia research in stroke and technical and logistical issues associated with the application of Hypothermia.
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A Pilot Dose-Escalation Safety Study of Tenecteplase in Acute Ischemic Stroke
TLDR
Overall, modified Rankin scores at 3 months were similar to those of historical controls treated with rtPA and not significantly different between treatment groups, suggesting TNK doses of 0.1 to 0.4 mg/kg are safe in ischemic stroke.
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Identification of nonischemic stroke mimics among 411 code strokes at the University of California, San Diego, Stroke Center.
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Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study
TLDR
In this prospective pilot study, the baseline NIHSS score was essential for prediction of acute ischemic stroke outcomes, followed by age; whereas traditional comorbidity index contributed little to the overall model.
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Translational Stroke Research: Vision and Opportunities
TLDR
Pharmacodynamics, pharmacokinetics, and target engagement in the human brain need to be further developed and optimized for stroke interventions so that drug level in brain tissue, time to initiation, and duration of treatment can be accurately measured in clinical trials.
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Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)
TLDR
Intravascular therapeutic hypothermia was confirmed to be safe and feasible in recombinant tissue-type plasminogen activator–treated acute ischemic stroke patients, and protocol changes designed to reduce pneumonia risk appeared to fail.
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