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Hemoglobin Desaturation after Succinylcholine-induced Apnea: A Study of the Recovery of Spontaneous Ventilation in Healthy Volunteers
Background Because of the rapid recovery of neuromuscular function after succinylcholine administration, there is a belief that patients will start breathing sufficiently rapidly to preventExpand
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Impact of Hypothermia on the Response to Neuromuscular Blocking Drugs
Muscle strength is reduced during hypothermia, both in the presence and in the absence of neuromuscular blocking drugs. A 2°C reduction in body temperature may double the duration of neuromuscularExpand
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Temperature-dependent Pharmacokinetics and Pharmacodynamics of Vecuronium
Background The authors evaluated the influence of temperature on the pharmacokinetics and pharmacodynamics of vecuronium because mild core hypothermia doubles its duration of action. MethodsExpand
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Anaphylactic reactions during induction of anaesthesia using rocuronium for muscle relaxation: A report including 3 cases
Anaphylaxis during induction of anaesthesia is a dreaded complication with a mortality rate of 3–6%, most frequently associated with the use of muscle relaxants. Current knowledge on this matter isExpand
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Rapid Tracheal Intubation with Large-Dose Rocuronium: A Probability-Based Approach
There are situations in anesthesia in which it may be desirable to achieve rapid tracheal intubation with perfect conditions, i.e., no coughing or straining. To determine the dose of rocuronium thatExpand
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Assessment of anaesthesia depth
ity and muscle relaxation (1). Anaesthesia implies that the patient neither perceives nor recalls pain 01 any event that occurred during surgery (2). Appropriate administration of anaesthetics takesExpand
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Safety and efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in cardiac patients undergoing noncardiac surgery
Background and objective The present randomized, safety-assessor blinded, placebo-controlled trial was designed to assess safety and efficacy of sugammadex, a novel selective relaxant-binding agent,Expand
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Rocuronium and cisatracurium‐positive skin tests in non‐allergic volunteers: determination of drug concentration thresholds using a dilution titration technique *
Background: Muscle relaxants are believed to be responsible for 2/3 of the cases of anaphylactic reactions during anesthesia. This assumption is based mainly on positive skin tests obtained inExpand
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Awareness in anaesthesia: Incidence, consequences and prevention
Awareness during anaesthesia is a state of consciousness that is revealed by explicit or implicit memory of intraoperative events. Although large clinical surveys indicate an incidence of explicitExpand
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The Influence of Mild Hypothermia on the Pharmacokinetics and Time Course of Action of Neostigmine in Anesthetized Volunteers
Background The pharmacokinetics, maximum effect, and time course of action of neostigmine were studied in seven human volunteers. Methods Each volunteer was studied twice, during both normothermiaExpand
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