• Publications
  • Influence
Calpain-Mediated Bid Cleavage and Calpain-Independent Bak Modulation: Two Separate Pathways in Cisplatin-Induced Apoptosis
TLDR
Calpain-mediated Bid cleavage is important in drug-induced apoptosis, and cisplatin induces at least two separate apoptotic signaling pathways resulting in Bid cleaved and Bak modulation, respectively. Expand
Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.
TLDR
It is shown that induced mouse CFSs relate to sites of spontaneous gaps and breaks and that CFS expression levels in chromosome bands are conserved between the two mouse strains and between syntenic mouse and human DNA segments, and suggest that the mechanisms that provoke instability at C FSs are evolutionarily conserved. Expand
Molecular mechanisms underlying interferon-α-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins
TLDR
The data suggest that the early decline in G1 Cdk activity, subsequent changes in phosphorylation of pocket proteins, and G1/G0 arrest following IFN-α treatment, is not primarily due to loss of the G1 kinase components, but result from the inhibitory action of CKIs on these complexes. Expand
An improved Hedley method for preparation of paraffin-embedded tissues for flow cytometric analysis of ploidy and S-phase.
TLDR
A modification of the Hedley-method for flow cytometric DNA analysis of paraffin-embedded tissues is presented and the improved method was applied to the estimation of frequencies of high-polyploid nuclei found in various diploid, tetraploids, and aneuploid human myosarcomas of the uterus. Expand
Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.
TLDR
The results indicate that the chronic enhancement of glucocorticoid signaling in pancreatic beta-cells results in hyperglycemia and impaired glucose tolerance, which may involve signaling pathways that participate in the regulation of insulin secretion via the alpha(2)-AR. Expand
Expression of CTLA‐4 by Human Monocytes
TLDR
The data provide the first evidence that CTLA‐4 is constitutively expressed by monocytes and thus might be important for the regulation of immune mechanisms associated with monocytes. Expand
Expression of glycolytic isoenzymes in activated human peripheral lymphocytes: cell cycle analysis using flow cytometry.
TLDR
Induction of glycolytic isoenzymes provides an excellent marker of T-cell activation and progression toward DNA synthesis. Expand
Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines.
TLDR
It is concluded that IFN-alpha-induced apoptosis seems to occur independent of cell growth inhibition, as there were no changes in Bcl-2 or Bax protein levels that could account for the apoptosis-inducing effects of IFn-alpha in these cell lines. Expand
The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis
TLDR
It is concluded that blocking of the MEK1/ERK pathway may, in some instances, potentiate the cytotoxic effect of cisplatin on human melanoma cell lines, whereas in other instances it may have a protective effect. Expand
Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development
TLDR
This study apparently indicates that Kaposi's sarcoma represents a unique variant of tumor growth with continues recruitment of tumor precursor cells as well as proliferation and decreased apoptosis of SC. Expand
...
1
2
3
4
5
...