Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- S. Kathiresan, O. Melander, +23 authors M. Orho-Melander
- Biology, Medicine
- Nature Genetics
- 13 January 2008
Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals… Expand
Randomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study
- L. Hansson, T. Hedner, P. Lund-Johansen, S. Kjeldsen, for the Nordil Study Group
- Medicine
- The Lancet
- 29 July 2000
BACKGROUND
Calcium antagonists are a first-line treatment for hypertension. The effectiveness of diltiazem, a non-dihydropyridine calcium antagonist, in reducing cardiovascular morbidity or mortality… Expand
Comparison of antihypertensive treatments in preventing cardiovascular events in elderly diabetic patients: results from the Swedish Trial in Old Patients with Hypertension–2
- L. Lindholm, L. Hansson, +7 authors U. de Faire
- Medicine
- Journal of hypertension
- 1 November 2000
Background The benefits of treating hypertension in elderly diabetic patients, in terms of achieving reductions in cardiovascular morbidity and mortality, have been documented in several recent… Expand
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
- M. Orho-Melander, O. Melander, +38 authors S. Kathiresan
- Biology, Medicine
- Diabetes
- 1 November 2008
OBJECTIVE—Using the genome-wide association approach, we recently identified the glucokinase regulatory protein gene (GCKR, rs780094) region as a novel quantitative trait locus for plasma… Expand
Blood pressure loci identified with a gene-centric array.
- T. Johnson, Tom R. Gaunt, +101 authors P. Munroe
- Biology, Medicine
- American journal of human genetics
- 9 December 2011
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain… Expand
Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum
- S. Kathiresan, O. Melander, +23 authors M. Orho-Melander
- Nature Genetics
- 2008
CASK is a multi-domain scaffolding protein that interacts with the transcription factor TBR1 and regulates expression of genes involved in cortical development such as RELN. Here we describe a… Expand
Perceived symptoms amongst hypertensive patients in routine clinical practice – a population‐based study
- K. Kjellgren, J. Ahlner, B. Dahlöf, H. Gill, T. Hedner, R. Säljö
- Medicine
- Journal of internal medicine
- 1 October 1998
Kjellgren KI, Ahlner J, Dahlöf B, Gill H, Hedner T, Säljö R (Faculty of Health Sciences, Linköping; Sahlgrenska University Hospital, Göteborg; and Linköping University, Linköping, Sweden). Perceived… Expand
COX-2-Specific Inhibitors – the Emergence of a New Class of Analgesic and Anti-inflammatory Drugs
- B. Everts, P. Währborg, T. Hedner
- Medicine
- Clinical Rheumatology
- 2000
Abstract: The prostaglandin series of bioactive compounds is formed by the interaction of two distinct but related enzymes, cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2). COX-1 is a… Expand
Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension?
- J. Hedner, H. Ejnell, J. Sellgren, T. Hedner, G. Wallin
- Medicine
- Journal of hypertension. Supplement : official…
- 1 December 1988
Muscle nerve sympathetic activity was recorded in six patients with the sleep apnoea syndrome (SAS). Compared with age- and sex-matched control patients, an increased activity during wakefulness was… Expand
Prospective randomized open blinded end-point (PROBE) study. A novel design for intervention trials. Prospective Randomized Open Blinded End-Point.
- L. Hansson, T. Hedner, B. Dahlöf
- Medicine
- Blood pressure
- 1992
A novel design for intervention studies is presented, the so called PROBE study (Prospective Randomized Open, Blinded End-point). This design is compared to the classical double-blind design. Among… Expand