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Inhibition of fatty acid synthesis by the antibiotic thiolactomycin.
The antibiotic thiolactomycin inhibits the growth of Escherichia coli K-12 and Pseudomonas aeruginosa 507 (beta-lactam supersensitive mutant). A micrograph of E. coli cells, which were grown at aExpand
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Mechanism of action of the antibiotic thiolactomycin inhibition of fatty acid synthesis of Escherichia coli.
Thiolactomycin, an antibiotic with the structure of (4S)-(2E,5E)-2,4,6-trimethyl-3-hydroxy-2,5,7-octatriene-4-thiolide, inhibits the incorporation of [14C]acetate into cellular fatty acids ofExpand
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Thiolactomycin, a new antibiotic. I. Taxonomy of the producing organism, fermentation and biological properties.
A strain of actinomycetes, isolated from a soil sample, has produced a novel antibiotic (C11H14O2S) containing a unique thiolactone moiety in its molecule. On the basis of taxonomic studies theExpand
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Penetration of macrolides into human polymorphonuclear leucocytes.
Five 14C-labelled macrolide antibiotics (erythromycin, josamycin, clarithromycin (TE-031), rokitamycin and roxithromycin) were studied for their transport into human polymorphonuclear leucocytes.Expand
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Thiolactomycin, a new antibiotic. II. Structure elucidation.
Thiolactomycin, a new antibiotic produced by a soil isolate, Nocardia sp. No. 2-200, is shown to have the structure (4S)-(2E, 5E)-2, 4, 6-trimethyl-3-hydroxy-2, 5, 7-octatriene-4-thiolide on theExpand
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Production of deoxyfrenolicin and a new antibiotic, frenolicin B by Streptomyces roseofulvus strain AM-3867.
Two antibiotics of frenolicin group, antibiotic AM-3867 I and II were isolated from the fermentation broth of Streptomyces roseofulvus strain No. AM-3867, a soil isolate. The former was a newExpand
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Role of Bacteroides uniformis in susceptibility of Ta:CF# 1 mice to infection by Treponema hyodysenteriae.
Among the various strains and colonies of mice tested specific-pathogen-free (SPF) Ta:CF#1 mice exhibited the highest susceptibility to Treponema hyodysenteriae infection. Staphylococcus epidermidisExpand
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The action mechanism of brefeldin A. I. Growth recovery of Candida albicans by lipids from the action of brefeldin A.
Brefeldin A is an antifungal antibiotic and a fatty acid derivative biosynthesized from palmitate (C16). The action mechanism of the antibiotic was studied using Candida albicans IAM 4888, the mostExpand
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The structures of fluopsins C and F.
Two new antibiotics, fluopsins C and F, have been isolated from the culture broth of Pseudomonas fluorescens and characterized as bis(N-methyl-N-thioformylhydroxylaminato)copper(II) (I) andExpand
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