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Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.
BACKGROUND & AIMS We tested whether the attenuation of experimental colitis by live probiotic bacteria is due to their immunostimulatory DNA, whether toll-like receptor (TLR) signaling is required,Expand
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase.
Epidemiological evidence points to the inverse relationship between microbial exposure and the prevalence of allergic asthma and autoimmune diseases in Westernized countries. The molecular basis forExpand
3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
  • T. Hayashi, J. Mo, +9 authors E. Raz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 20 November 2007
3-Hydroxyanthranilic acid (HAA), a compound generated during tryptophan metabolism initiated by indoleamine 2,3-dioxygenase, is known to induce T cell death, but its molecular target is not known.Expand
Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis.
BACKGROUND & AIMS Impaired mucosal barrier, cytokine imbalance, and dysregulated CD4(+) T cells play important roles in the pathogenesis of experimental colitis and human inflammatory bowel disease.Expand
The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity
Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here,Expand
IFN-αβ Promote Priming of Antigen-Specific CD8+ and CD4+ T Lymphocytes by Immunostimulatory DNA-Based Vaccines1
Immunostimulatory sequence (ISS) DNA containing unmethylated CpG dinucleotides stimulate NK and APC to secrete proinflammatory cytokines, including IFN-αβ and -γ, TNF-α, and IL-6 and -12, and toExpand
Induction of a homeostatic circuit in lung tissue by microbial compounds.
TGFbeta presented and activated by integrin alphavbeta6 expressed on alveolar epithelial cells (AEC) continuously inhibits the functionality of alveolar macrophages (AM). Despite this inhibition, AMExpand
Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand
The immunotherapeutic activity of Toll-like receptor (TLR) activators has been difficult to exploit because of side effects related to the release and systemic dispersion of proinflammatoryExpand
Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia
Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have beenExpand
TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant
High mobility group box protein 1 (HMGB1) acts as an endogenous danger molecule that is released from necrotic cells and activated macrophages. We have previously shown that peptide Hp91, whoseExpand