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Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis.
It was revealed that Ca-SP selectively inhibited the penetration of virus into host cells, and retention of molecular conformation by chelation of calcium ion with sulfate groups was suggested to be indispensable to its antiviral effect. Expand
A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities.
Ca-SP can be a candidate agent for an anti-HIV therapeutic drug that might overcome the disadvantages observed in many sulfated polysaccharides, because it had very low anticoagulant activity, and showed a much longer half-life in the blood of mice when compared with that of DS. Expand
Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV.
These in vitro findings demonstrate that the essential oils provide virucidal activity against enveloped viruses by interfering with the function of virus envelope. Expand
Unusual CT and MR appearance of an epidermoid tumor of the cerebellopontine angle.
An unusual epidermoid tumor of the cerebellopontine angle that appeared hyperdense on CT scans and hyperintense on T1- and T2-weighted MR images was caused by a high protein concentration within the contents of the cyst. Expand
Characterization of antiviral activity of a sesquiterpene, triptofordin C-2.
The activities of 13 sesquiterpenes isolated from Tripterygium wilfordii Hook fil. var. regelii Makino were studied against herpes simplex virus type 1 (HSV-1) in vitro. Among these compounds, onlyExpand
A novel antivirally active fucan sulfate derived from an edible brown alga, Sargassum horneri.
A novel fucan sulfate (Hor-1) was isolated from the hot water extract of an edible brown alga and exhibited inhibitory activity against replication of herpes simplex virus type 1 with similar potency to Na-HOR. Expand
Metabolism of paeoniflorin and related compounds by human intestinal bacteria.
Through screening of various strains of intestinal bacteria from human feces, Peptostreptococcus anaerobius was shown to have potent ability to transform paeoniflorin to pae onimetaboline I. Expand
Improving effects of the extracts from Eugenia uniflora on hyperglycemia and hypertriglyceridemia in mice.
The inhibition of the increase in plasma glucose level by NP-3, 4, 5 and 6 in the oral sucrose tolerance test and the inhibition of a rise in plasma triglycerides byNP-3 and 4 in the Oral corn oil tolerance test were apparently due to the inhibited of the decomposition of carbohydrates and fats in the intestine, respectively. Expand
Effects of structural modification of calcium spirulan, a sulfated polysaccharide from Spirulina platensis, on antiviral activity.
Replacement of calcium ion with sodium and potassium ions maintained the antiviral activity while divalent and trivalent metal cations reduced the activity. Expand
Evaluation of (1R,2R)-1-(5'-methylfur-3'-yl)propane-1,2,3-triol, a sphydrofuran derivative isolated from a Streptomyces species, as an anti-herpesvirus drug.
The results, taken together, suggest that MFPT might act by limiting the maturation of HSV-specific glycoproteins, particularly of HSv-1 gC. Expand