Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes.
- T. Hashizume, S. Imaoka, Y. Funae
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 2002
It is demonstrated for the first time that, in human intestinal microsomes, both CYP2J and CYP4F subfamilies not only metabolize endogenous substrates but also are involved in the drug metabolism.
Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins
- Toru Usui, M. Mise, T. Hashizume, M. Yabuki, S. Komuro
- Medicine, BiologyDrug Metabolism And Disposition
- 1 December 2009
The findings suggest that the combination of CB amount and daily dose can estimate the risk of idiosyncratic DILI.
Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia
- Yang Xu, T. Hashizume, K. Thummel
- Biology, ChemistryMolecular Pharmacology
- 1 January 2006
Induction of CYP3A4-dependent 1,25(OH)2D3 metabolism by antiepileptic drugs and other PXR ligands may diminish intestinal effects of the hormone and contribute to osteomalacia.
Identification of non-functional allelic variant of CYP1A2 in dogs.
- M. Mise, T. Hashizume, S. Matsumoto, Y. Terauchi, T. Fujii
- BiologyPharmacogenetics (London)
- 1 November 2004
The results indicate that the polymorphic expression of CYP1A2 protein observed in the previous study is caused by a single nucleotide polymorphism on CYP 1A2 coding region, important in the pharmaceutical and the veterinary fields.
cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine.
- T. Hashizume, S. Imaoka, Y. Funae
- Biology, ChemistryBiochemical and Biophysical Research…
- 2 February 2001
CYP4F12 has a different profile of substrate specificity from other CYP4F isoforms, enzymes responsible for metabolizing endogenous autacoids, therefore suggesting that it may play an important role in xenobiotic biotransformation in the human small intestine.
Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs.
- S. Imaoka, T. Hashizume, Y. Funae
- Biology, ChemistryDrug Metabolism and Pharmacokinetics
- 2005
A systematic analysis of P 450 expression in various tissues and of its catalytic property may provide valuable information on the physiological roles of P450s in each tissue.
Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs.
- M. Mise, Seiji Yadera, T. Fujii
- Biology, ChemistryDrug Metabolism And Disposition
- 1 February 2004
The results indicate that AC-3933 polymorphic hydroxylation arises from the polymorphic expression of CYP1A2 in dogs, which might involve genetic polymorphism of the CYP 1A2 gene.
A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.
- T. Hashizume, M. Mise, H. Miyazaki
- Biology, ChemistryDrug Metabolism And Disposition
- 1 June 2001
Results suggest that the small intestinal CYP4F enzyme, P450 MI-2, can play an important role in the metabolism of drugs given orally and is mainly responsible for hydroxylation of ebastine in monkey small intestinal microsomes.
Bilirubin is oxidized in rats treated with endotoxin and acts as a physiological antioxidant synergistically with ascorbic acid in vivo.
- T. Yamaguchi, F. Horio, H. Nakajima
- Biology, MedicineBiochemical and Biophysical Research…
- 5 September 1995
It is suggested that bilirubin is oxidized in rats treated with LPS and acts as a physiological antioxidant synergistically with ascorbic acid in vivo.
An Inducible Cytochrome P450 3A4-Dependent Vitamin D Catabolic Pathway
- Zhican Wang, Yvonne S. Lin, K. Thummel
- Biology, MedicineMolecular Pharmacology
- 1 April 2012
It is suggested that CYP3A4-dependent 25OHD3 metabolism may play an important role in the regulation of vitamin D3 in vivo and in the etiology of drug-induced osteomalacia.
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