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Itch-Scratch Responses Induced by Lysophosphatidic Acid in Mice
TLDR
Findings suggest that LPA-induced ISRs are attributable to histamine- and substance-P-mediated pathways, and the Rho/ROCK-mediated pathway may be involved. Expand
Lysophosphatidic acid enhances airway response to acetylcholine in guinea pigs.
TLDR
Inhalation of lysophosphatidic acid (LPA, 1-100 microg/ml) for 2 min enhanced the airway response induced by intravenous injection of ACh in guinea pigs, suggesting that the enhancement ofAirway response to ACh induced by LPA may be due to the activation of capsaicin-sensitive fibers. Expand
Distinct Effects of Tissue-Type Plasminogen Activator and SMTP-7 on Cerebrovascular Inflammation Following Thrombolytic Reperfusion
TLDR
Relatively mild cerebrovascular inflammation and cerebral infarction in the SMTP-7 mice, compared with in rt-PA mice, is thought to be caused at least in part by direct antioxidative actions of SM TP-7 in ECs. Expand
Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs.
TLDR
It is suggested that LPA-induced airway hyperresponsiveness is attributable to activation of the Rho/ROCK-mediated pathway via endothelial cell differentiation gene (EDG) receptors, probably EDG 7. Expand
Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.
TLDR
The findings indicate that plasma exudation induced by LPA is mediated by histamine release from mast cells via LPA receptor(s), presumably LPA1 and/or LPA3, coupled to G(i/o) proteins, and point to a role of LPA in the pathomechanisms of various allergic disorders. Expand
A novel finding of a low-molecular-weight compound, SMTP-7, having thrombolytic and anti-inflammatory effects in cerebral infarction of mice
TLDR
Results indicate that SMTP-7 shows potential thrombolytic and anti-inflammatory effects as well as a wide therapeutic time window and little hemorrhagic region compared with that of t-PA, and this novel low-molecular-weight compound may represent a novel approach for the treatment of cerebral infarction. Expand
A novel embolic model of cerebral infarction and evaluation of Stachybotrys microspora triprenyl phenol-7 (SMTP-7), a novel fungal triprenyl phenol metabolite.
TLDR
The results indicate that this model may be useful for understanding the pathophysiological mechanisms of cerebral infarction and evaluating the effects of therapeutic agents, and SMTP-7 is a promising approach to extend the therapeutic time window. Expand
Alterations of Glucose-Dependent and -Independent Bladder Smooth Muscle Contraction in Spontaneously Hypertensive and Hyperlipidemic Rat
TLDR
The results suggested that bladder contractility dysfunction in SHHR is attributable to alteration of rho kinase activity and the DG-PKC pathway, which may occur prior to chronic hyperglycemia onset in progressive hypertension and hyperlipidemia. Expand
A novel approach for the determination of contractile and calcium responses of the basilar artery employing real-time confocal laser microscopy.
TLDR
Confocal laser microscopy is a suitable tool for estimation of small artery function because it offers reproducibility and quantifiable effects at the tissue level as well as at the level of the individual cell. Expand
Evaluation of the effects of a new series of SMTPs in the acetic acid‐induced embolic cerebral infarct mouse model
TLDR
Evaluating and comparing a new series of SMTPs in the acetic acid‐induced embolic cerebral infarct mouse model indicates that SMTP‐22 andSMTP‐43 have potential as medicinal compounds for the treatment of embolic cortex infarction. Expand
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