T. Hashimoto

Publications210
h-index47
Citations6,929
Highly Influential Citations142
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Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase…
Long-chain 3-hydroxyacyl-CoA dehydrogenase was extracted from the washed membrane fraction of frozen rat liver mitochondria with buffer containing detergent and then was purified. This enzyme is an… Expand
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Insertion of the 70-kDa Peroxisomal Membrane Protein into Peroxisomal Membranes in Vivo and in Vitro(*)
Biosynthesis and intracellular transport of 70-kDa peroxisomal membrane protein (PMP70) has been studied in rat hepatoma, H-4-II-E cells. Pulse-chase analysis showed that a newly synthesized S-PMP70… Expand
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Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat.
The effects of sesamin, one of the most abundant lignans in sesame seed, on hepatic fatty acid oxidation were examined in rats that were fed experimental diets containing various amounts (0%, 0.1%,… Expand
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Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.
Freeze-thawed rat liver mitochondria were extensively washed with potassium phosphate, pH 7.5, and the residue was extracted with 10 mM potassium phosphate, pH 7.5, 1% (w/v) sodium cholate, 0.5 M… Expand
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Comparative effects of perilla and fish oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver.
The activity and mRNA level of hepatic enzymes in fatty acid oxidation and synthesis were compared in rats fed diets containing either 15% saturated fat (palm oil), safflower oil rich in linoleic… Expand
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Characterization of the signal peptide at the amino terminus of the rat peroxisomal 3-ketoacyl-CoA thiolase precursor.
The amino-terminal presequences of rat peroxisomal 3-ketoacyl-CoA thiolase precursors (types A and B) were reported to be cleavable signal peptides for peroxisomal protein translocation. In the… Expand
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The presence of a new 3-oxoacyl-CoA thiolase in rat liver peroxisomes.
A novel 3-oxacyl-CoA thiolase was found in rat liver. This thiolase, mitochondrial general 3-oxacyl-CoA thiolase and acetoacetyl-CoA thiolase were purified from the rat liver after the induction of… Expand
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Two mitochondrial 3-hydroxyacyl-CoA dehydrogenases in bovine liver.
3-Hydroxyacyl-CoA dehydrogenase catalyzes the third reaction of fatty acid beta-oxidation spiral. There are three enzymes catalyzing the 3-hydroxyacyl-CoA dehydrogenase, mitochondrial enoyl-CoA… Expand
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Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.
The second and third reactions of the peroxisomal beta-oxidation spiral are thought to be catalyzed by enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase bifunctional protein (L-bifunctional… Expand
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Purification and properties of acyl-CoA oxidase from rat liver.
Acyl-CoA oxidase, the initial enzyme of the peroxisomal beta-oxidation system, was purified from rat liver. The final preparation was judged to be nearly homogeneous from the results of sedimentation… Expand
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