• Publications
  • Influence
Photodynamic therapy: a new antimicrobial approach to infectious disease?
  • M. Hamblin, T. Hasan
  • Biology, Medicine
  • Photochemical & photobiological sciences…
  • 30 April 2004
Photodynamic therapy (PDT) employs a non-toxic dye, termed a photosensitizer (PS), and low intensity visible light which, in the presence of oxygen, combine to produce cytotoxic species. PDT has theExpand
  • 1,398
  • 41
Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.
The purpose of this review is to present the current state of the role of imaging in photodynamic therapy (PDT). In order for the reader to fully appreciate the context of the discussions embodied inExpand
  • 1,335
  • 16
Photodynamic therapy for Staphylococcus aureus infected burn wounds in mice.
The rise of multiply antibiotic resistant bacteria has led to searches for novel antimicrobial therapies to treat infections. Photodynamic therapy (PDT) is a potential candidate; it uses theExpand
  • 148
  • 8
Development and applications of photo-triggered theranostic agents.
Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine forExpand
  • 365
  • 6
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
5-Aminolaevulinic acid (ALA)-induced porphyrin biosynthesis and phototoxicity in vitro was investigated in five malignant and two normal cell lines. Intracellular protoporphyrin IX (PpIX) content wasExpand
  • 248
  • 6
Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer
Background:Patients with pancreatic cancer have a poor prognosis apart from the few suitable for surgery. Photodynamic therapy (PDT) produces localised tissue necrosis but previous studies using theExpand
  • 193
  • 6
  • PDF
Vascular and cellular targeting for photodynamic therapy.
Photodynamic therapy (PDT) involves the combination of photosensitizers (PS) with light as a treatment, and has been an established medical practice for about 10 years. Current primary applicationsExpand
  • 192
  • 6
The effects of aggregation, protein binding and cellular incorporation on the photophysical properties of benzoporphyrin derivative monoacid ring A (BPDMA).
Absorption, fluorescence and laser flash photolysis spectroscopies were used to investigate the effects of self-aggregation, binding to human serum albumin and incorporation in cancer cells on theExpand
  • 168
  • 6
Clinical manifestations and classification of Old World cutaneous leishmaniasis
With the migratory trends amongst populations during the last decade (urbanization, political conflicts, etc.), there has been an increase in the incidence of Old World cutaneous leishmaniasis (CL).Expand
  • 83
  • 6
Vascular targeting in photodynamic occlusion of subretinal vessels.
PURPOSE To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateralExpand
  • 235
  • 5