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Photodynamic therapy: a new antimicrobial approach to infectious disease?
Photodynamic therapy (PDT) employs a non-toxic dye, termed a photosensitizer (PS), and low intensity visible light which, in the presence of oxygen, combine to produce cytotoxic species. PDT has the… Expand
Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.
The purpose of this review is to present the current state of the role of imaging in photodynamic therapy (PDT). In order for the reader to fully appreciate the context of the discussions embodied in… Expand
Photodynamic therapy for Staphylococcus aureus infected burn wounds in mice.
- S. A. G. Lambrechts, T. Demidova, M. Aalders, T. Hasan, M. Hamblin
- Photochemical & photobiological sciences…
- 28 June 2005
The rise of multiply antibiotic resistant bacteria has led to searches for novel antimicrobial therapies to treat infections. Photodynamic therapy (PDT) is a potential candidate; it uses the… Expand
Development and applications of photo-triggered theranostic agents.
Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for… Expand
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
5-Aminolaevulinic acid (ALA)-induced porphyrin biosynthesis and phototoxicity in vitro was investigated in five malignant and two normal cell lines. Intracellular protoporphyrin IX (PpIX) content was… Expand
Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer
Background:Patients with pancreatic cancer have a poor prognosis apart from the few suitable for surgery. Photodynamic therapy (PDT) produces localised tissue necrosis but previous studies using the… Expand
Vascular and cellular targeting for photodynamic therapy.
- B. Chen, B. Pogue, P. J. Hoopes, T. Hasan
- Biology, Medicine
- Critical reviews in eukaryotic gene expression
Photodynamic therapy (PDT) involves the combination of photosensitizers (PS) with light as a treatment, and has been an established medical practice for about 10 years. Current primary applications… Expand
The effects of aggregation, protein binding and cellular incorporation on the photophysical properties of benzoporphyrin derivative monoacid ring A (BPDMA).
- B. Aveline, T. Hasan, R. Redmond
- Chemistry, Medicine
- Journal of photochemistry and photobiology. B…
- 1 October 1995
Absorption, fluorescence and laser flash photolysis spectroscopies were used to investigate the effects of self-aggregation, binding to human serum albumin and incorporation in cancer cells on the… Expand
Clinical manifestations and classification of Old World cutaneous leishmaniasis
With the migratory trends amongst populations during the last decade (urbanization, political conflicts, etc.), there has been an increase in the incidence of Old World cutaneous leishmaniasis (CL).… Expand
Vascular targeting in photodynamic occlusion of subretinal vessels.
- U. Schmidt-Erfurth, T. Hasan, E. Gragoudas, N. Michaud, T. Flotte, R. Birngruber
- 1 December 1994
PURPOSE To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateral… Expand