Genetic studies of body mass index yield new insights for obesity biology
- A. Locke, Bratati Kahali, E. Speliotes
- 11 February 2015
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- J. Lambert, C. Ibrahim-Verbaas, P. Amouyel
- BiologyNature Genetics
- 27 October 2013
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
- Tanya M. Teslovich, K. Musunuru, S. Kathiresan
- 1 August 2010
The results identify several novel loci associated with plasma lipids that are also associated with CAD and provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- E. Speliotes, C. Willer, R. Loos
- Biology, Medicine
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates
- S. Studenski, K. Peters, M. Vassileva
- MedicineThe journals of gerontology. Series A, Biological…
- 31 March 2014
Based on the analyses presented in this series, the final recommended cutpoints for weakness are grip strength <26kg for men and <16kg for women, and for low lean mass, appendicular lean mass adjusted for body mass index <0.789 forMen and women.
Discovery and Refinement of Loci Associated with Lipid Levels
- C. Willer, Ellen M. Schmidt, G. Abecasis
- BiologyNature Genetics
- 6 October 2013
It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index.
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
- R. Fielding, B. Vellas, M. Zamboni
- MedicineJournal of the American Medical Directors…
- 1 May 2011
Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old.
- K. Adams, A. Schatzkin, M. Leitzmann
- MedicineNew England Journal of Medicine
- 24 August 2006
Excess body weight during midlife, including overweight, is associated with an increased risk of death in men and women aged 50 to 71 years old in the National Institutes of Health-AARP cohort.
Elevated C-reactive protein levels in overweight and obese adults.
- M. Visser, L. Bouter, G. Mcquillan, M. Wener, T. Harris
- 8 December 1999
Higher BMI is associated with higher CRP concentrations, even among young adults aged 17 to 39 years, and these findings suggest a state of low-grade systemic inflammation in overweight and obese persons.
Genome-wide association study of blood pressure and hypertension
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7.