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Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
TLDR
The results identify several novel loci associated with plasma lipids that are also associated with CAD and provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD. Expand
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
TLDR
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease. Expand
Genetic studies of body mass index yield new insights for obesity biology
TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility. Expand
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
TLDR
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation. Expand
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
TLDR
Sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health, and patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions. Expand
Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old.
TLDR
Excess body weight during midlife, including overweight, is associated with an increased risk of death in men and women aged 50 to 71 years old in the National Institutes of Health-AARP cohort. Expand
The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates
TLDR
Based on the analyses presented in this series, the final recommended cutpoints for weakness are grip strength <26kg for men and <16kg for women, and for low lean mass, appendicular lean mass adjusted for body mass index <0.789 forMen and women. Expand
Genome-wide association study of blood pressure and hypertension
TLDR
A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7. Expand
Elevated C-reactive protein levels in overweight and obese adults.
TLDR
Higher BMI is associated with higher CRP concentrations, even among young adults aged 17 to 39 years, and these findings suggest a state of low-grade systemic inflammation in overweight and obese persons. Expand
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study.
TLDR
Although the loss of muscle mass is associated with the decline in strength in older adults, this strength decline is much more rapid than the concomitant loss of Muscle mass, suggesting a decline in muscle quality. Expand
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