• Publications
  • Influence
Pyramidal cell communication within local networks in layer 2/3 of rat neocortex.
The extent to which neocortical pyramidal cells function as a local network is determined by the strength and probability of their connections. By mapping connections between pyramidal cells we showExpand
  • 472
  • 55
Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms of seizure induction remain elusive. Here, we performed video-EEG recordings inExpand
  • 377
  • 34
Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity
The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB1 cannabinoid receptors (CB1Rs) are enriched in the axonal growth cones ofExpand
  • 373
  • 27
Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB functions duringExpand
  • 207
  • 19
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
In utero exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure andExpand
  • 225
  • 17
The emerging functions of endocannabinoid signaling during CNS development.
In the postnatal brain, endocannabinoids acting as retrograde messengers regulate the function of many synapses. By contrast, the understanding of endocannabinoid functions that regulate fundamentalExpand
  • 275
  • 15
Integration of electrophysiological recordings with single-cell RNA-seq data identifies novel neuronal subtypes
Traditionally, neuroscientists have defined the identity of neurons by the cells' location, morphology, connectivity and excitability. However, the direct relationship between these parameters andExpand
  • 204
  • 15
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
One size does not fit all Oligodendrocytes are best known for their ability to myelinate brain neurons, thus increasing the speed of signal transmission. Marques et al. surveyed oligodendrocytes ofExpand
  • 329
  • 14
Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration
The μ-δ opioid heteromer may be a target for alleviation of chronic pain. Drug-Induced Heteromers Opioid receptors are G protein–coupled receptors and are divided into μ, δ, and κ subtypes. HomomersExpand
  • 160
  • 14
Reversible Paired Helical Filament-Like Phosphorylation of Tau Is an Adaptive Process Associated with Neuronal Plasticity in Hibernating Animals
Neurofibrillary pathology [paired helical filaments (PHFs)] formed by the microtubule-associated protein tau in a hyperphosphorylated form is a major hallmark of Alzheimer's disease and relatedExpand
  • 284
  • 13