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Autophagosomes form at ER–mitochondria contact sites
Autophagy is a tightly regulated intracellular bulk degradation/recycling system that has fundamental roles in cellular homeostasis. Autophagy is initiated by isolation membranes, which form andExpand
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Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures.
The mouse Nedd5 gene encodes a 41.5-kD GTPase similar to the Saccharomyces and Drosophila septins essential for cytokinesis. Nedd5 accumulates near the contractile ring from anaphase throughExpand
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Identification and Characterization of Nuclear Pore Complex Components in Arabidopsis thaliana[W][OA]
Interactive proteomics technology was used to identify Arabidopsis nucleoporins, which are components of the nuclear pore complex (NPC). Nucleoporin domain organization is similar in plants,Expand
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Meiotic Proteins Bqt1 and Bqt2 Tether Telomeres to Form the Bouquet Arrangement of Chromosomes
In many organisms, meiotic chromosomes are bundled at their telomeres to form a "bouquet" arrangement. The bouquet formation plays an important role in homologous chromosome pairing and thereforeExpand
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Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells.
Using a computerized fluorescence microscope system to observe fluorescently stained cellular structures in vivo, we have examined the dynamics of chromosomes and microtubules during the process ofExpand
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Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF.
Loss of emerin, a lamin-binding nuclear membrane protein, causes Emery-Dreifuss muscular dystrophy. We analyzed 13 site-directed mutations, and four disease-causing mutations that do not disruptExpand
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Dynamics of homologous chromosome pairing during meiotic prophase in fission yeast.
Pairing of homologous chromosomes is important for homologous recombination and correct chromosome segregation during meiosis. It has been proposed that telomere clustering, nuclear oscillation, andExpand
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Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly
Assembly of the nuclear envelope (NE) in telophase is essential for higher eukaryotic cells to re-establish a functional nucleus. Time-lapse, FRAP and FRET analyses in human cells showed thatExpand
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Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
Yeast Mre11 functions with Rad50 and Xrs2 in a complex that has pivotal roles in homologous recombination (HR) and non‐homologous end‐joining (NHEJ) DNA double‐strand break (DSB) repair pathways.Expand
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Telomere-led premeiotic chromosome movement in fission yeast.
The movement of chromosomes that precedes meiosis was observed in living cells of fission yeast by fluorescence microscopy. Further analysis by in situ hybridization revealed that the telomeresExpand
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