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The Discovery and Development of Cisplatin
Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, subsequent introduction into the clinic,Expand
Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs
The hydrophobicity of platinum drugs correlates with platinum sequestration in the peripheral nervous system but not with neurotoxicity, and differences in the reactivity of platinum complexes accounts for some of the variation in their neurotoxicity. Expand
Platinum(IV) antitumour compounds: their bioinorganic chemistry
This article reviews the investigations undertaken into platinum(IV) antitumour compounds since Barnett Rosenberg first noted the activity of platinum(IV) complexes. The chemical and pharmacologicalExpand
Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
The proposed curative properties of Cu-based non-steroidal anti-inflammatory drugs (NSAIDs) have led to the development of numerous Cu(II) complexes of NSAIDs with enhanced anti-inflammatory activityExpand
Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin.
It is shown here that the permeability coefficient of cisplatin increases significantly with the chloride concentration of the medium, which supports the hypothesis that cis platin can enter cells via passive permeation through the lipid phase of the membrane, but becomes trapped within the cytoplasm because dissociation of chloride ligands yields a membrane-impermeant positively-charged aqua derivative. Expand
Molecular modeling of inorganic compounds
PART I: Theory INTRODUCTION Molecular Modeling Historical Background MOLECULAR MOEDLING METHODS IN BRIEF Molecular Mechanics Quantum Mechanics Other Methods PARAMETERIZATION, APPROXIMATIONS ANDExpand
Slowing of cisplatin aquation in the presence of DNA but not in the presence of phosphate: improved understanding of sequence selectivity and the roles of monoaquated and diaquated species in the
Comparison of the rates of disappearance of cisplatin in reactions at single defined GpG, ApG, GpA, G pTpG and 1,2-interstrand GG binding sites shows that the adduct profile is determined at the level of monofunctional adduct formation. Expand
Stereoselective peripheral sensory neurotoxicity of diaminocyclohexane platinum enantiomers related to ormaplatin and oxaliplatin.
Pt(DACH) derivatives exhibit enantiomeric-selective peripheral sensory neurotoxicity during repeated dosing in rats favouring S,S isomers (less neurotoxic) and exhibited less chiral discrimination in their accumulation within peripheral nerves and in vitro anti-tumour activity. Expand
Stabilization of cobalt(I) by the tripodal ligandstris(2-pyridyl)methane and tris(2-pyridyl)phosphine. Structural,spectroscopic and ab initio studies of the[CoL2]n+ species
The nature of bonding in a series of complexes [CoL 2 ] n + [L = the tripodal ligand tris(2-pyridyl)methane or tris(2-pyridyl)phosphine, n = 1–3] has been investigated by single-crystalExpand
Platinum drug distribution in cancer cells and tumors.
Alice Klein's research focuses on developing novel platinum(IV)-intercalator hybrid complexes and investigating their potential as antitumour agents in cells and the search for new platinum anticancer drugs is driven by the need to overcome the side effects and limited tumor penetration of existing platinum agents. Expand