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Dual site model for the organogenic activity of angiogenin.
These results identify the residues from 60 to 68 as a region of angiogenin that is part of a cell-surface receptor binding site that serves as the basis for a dual site model of the organogenic activity of ang iogenin. Expand
Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis).
A soluble enzyme preparation from the leaves of sweet marjoram catalyzes the divalent cation-dependent cyclization of geranyl pyrophosphate to the bicyclic monoterpene alcohols (+)-[ 6-3H]cis- and (+-[6- 3H]-transsabinene hydrate, providing labeling patterns consistent with current mechanistic considerations. Expand
Importance of asparagine-61 and asparagine-109 to the angiogenic activity of human angiogenin.
The results indicate that the combination of ribonucleolytic activity and receptor-binding capacity is not sufficient for angiogenic activity and that Asn-61 and AsN-109 within the noncatalytic site are required for some additional function, as yet undefined. Expand
Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate.
The results define the overall stereochemistry of the coupled isomerization-cyclization to sabinene hydrate, demonstrate the 1,2-hydride shift, and confirm the electrophilic nature of this enzymatic reaction type. Expand
Hydrolysis of dolichyl esters by oviduct membranes and characterization of endogenous dolichyl esters.
The fact that the highest esterase activity is found in membranes from chicks withdrawn from hormone and that only 20% of the dolichol is esterified argues against a role for Dol-esters as a reservoir of dolICHol for conversion to Dol-P. Expand