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Dual site model for the organogenic activity of angiogenin.
- T. Hallahan, R. Shapiro, B. Vallee
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 March 1991
These results identify the residues from 60 to 68 as a region of angiogenin that is part of a cell-surface receptor binding site that serves as the basis for a dual site model of the organogenic activity of ang iogenin. Expand
Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis).
A soluble enzyme preparation from the leaves of sweet marjoram catalyzes the divalent cation-dependent cyclization of geranyl pyrophosphate to the bicyclic monoterpene alcohols (+)-[ 6-3H]cis- and (+-[6- 3H]-transsabinene hydrate, providing labeling patterns consistent with current mechanistic considerations. Expand
Importance of asparagine-61 and asparagine-109 to the angiogenic activity of human angiogenin.
The results indicate that the combination of ribonucleolytic activity and receptor-binding capacity is not sufficient for angiogenic activity and that Asn-61 and AsN-109 within the noncatalytic site are required for some additional function, as yet undefined. Expand
Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate.
The results define the overall stereochemistry of the coupled isomerization-cyclization to sabinene hydrate, demonstrate the 1,2-hydride shift, and confirm the electrophilic nature of this enzymatic reaction type. Expand
Hydrolysis of dolichyl esters by oviduct membranes and characterization of endogenous dolichyl esters.
- T. Malvar, T. Hallahan, D. Beach, J. J. Lucas
- Chemistry, Medicine
- Archives of biochemistry and biophysics
- 1 May 1985
The fact that the highest esterase activity is found in membranes from chicks withdrawn from hormone and that only 20% of the dolichol is esterified argues against a role for Dol-esters as a reservoir of dolICHol for conversion to Dol-P. Expand
357: Skewed to the left: under-measurement of NT's and implications for screening efficiency
737: Impact of smoking on first trimester dried blood free beta HCG and PAPP-A
731: Management of the CVS window in first trimester Down syndrome screening