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Roles of uptake1 and catechol-O-methyltransferase in removal of circulating catecholamines in the rabbit.
TLDR
Comparison of the desipramine-sensitive components of ERS and ERP indicated that for uptake1 NE was the preferred substrate in the systemic circulation and DA was preferred in the pulmonary circulation.
Assay of catecholamines and dihydroxyphenylethyleneglycol in human plasma and its application in orthostasis and mental stress.
TLDR
The simultaneous measurement of plasma NA and DOPEG may help to distinguish between various types of activation of the sympathetic nervous system.
Effects of N‐ethylmaleimide on 5‐hydroxytryptamine transport and sodium content in rabbit platelets
TLDR
NEM inhibits 5‐HT transport by inhibiting the Na+/K+‐ATPase and not by a direct interaction with the5‐HT carrier, which hinders 5‐ HT inward transport.
Plasma 3,4-dihydroxyphenylglycol as a tool to assess the role of neuronal uptake in the anaesthetized rabbit
TLDR
Investigation of the role of neuronal uptake in the appearance in plasma of the primary noradrenaline metabolite 3,4-dihydroxyphenylglycol (DOPEG) found that, in the absence of infused nor adrenaline, the average norad Renaline concentration at all Noradrenergic neuroeffector junctions of the rabbit is 3.2 times as high as that in plasma.
Total body, systemic and pulmonary clearance and fractional extraction of unlabelled and differently 3H-labelled noradrenaline in the anaesthetized rabbit
TLDR
Estimates of the following steady-state kinetic parameters for infused noradrenaline were obtained: pulmonary, systemic as well as total body clearance, suggesting that there was little, if any, overflow of endogenous nor adrenaline into plasma during passage through the pulmonary circulation.
Plasma concentrations of noradrenaline and 3,4-dihydroxyphenylethyleneglycol under conditions of enhanced sympathetic activity
TLDR
Changes in plasma DOPEG brought about by changes in sympathetic tone are presynaptic in origin and probably stems from intraneuronal noradrenaline leaking out of the storage vesicles of peripheral sympathetic neurones and may in part also be derived from the central nervous system.
The synaptic noradrenaline concentration in humans as estimated from simultaneous measurements of plasma noradrenaline and dihydroxyphenylglycol (DOPEG).
TLDR
A linear relationship between plasma DOPEG and plasma noradrenaline (NA; abscissa) was found during orthostasis as well as during NA infusion, which suggests that the NA concentration in the synaptic cleft is markedly higher than in plasma.
Plasma Clearances and Extractions of Four Catecholamines in the Anesthetized Rabbit: The Role of Amine Removal by Blood Cells
TLDR
In vitro experiments, in which whole rabbit blood was incubated in the presence of added NA, A, ISO, and DA, showed a pronounced ability of blood cells to remove catecholamines from plasma at rates increasing in the order of NA < A < ISO < DA.
The heterogeneity of the neuronal distribution of exogenous noradrenaline in the rat vas deferens
TLDR
It is proposed that the various “compartments” and “pools” of noradrenaline described in the literature reflect the two heterogeneities described here.
Effects of nisoldipine on stress-induced changes in haemodynamics and plasma catecholamines in normotensives and hypertensives.
TLDR
The effectiveness of nisoldipine in lowering BP was the more pronounced the higher the BP to begin with and did not attenuate exercise- or stress-induced increases in plasma catecholamines.
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