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The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs.
TLDR
The study shows that some parts of the MC system are highly conserved through vertebrate evolution, such as regions in POMC coding for ACTH, alpha- MSH, and beta-MSH, the C-terminal region of AGRP, key binding units within the MC1R, MC2R,MC4R, and MC5R, synteny blocks around the MCRs, and pharmacological properties of theMC2R. Expand
Cloning of two melanocortin (MC) receptors in spiny dogfish: MC3 receptor in cartilaginous fish shows high affinity to ACTH-derived peptides while it has lower preference to gamma-MSH.
TLDR
The first molecular characterization of a MC3R in fish is described, indicating that many of the important elements of the MC system existed before radiation of gnathostomes, early in vertebrate evolution, at least 450 million years ago. Expand
Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes.
TLDR
The first cloning, 3D (three-dimensional) modelling, pharmacological characterization and tissue distribution of two melanocortin (MC) receptors in rainbow trout suggest that these two receptors have a closer evolutionary relationship than the other MC receptor subtypes. Expand
Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes
TLDR
This study shows presence of MC receptors in agnathans indicating early signs of specific functions of melanocortin receptor subtypes. Expand
New genomic and fossil data illuminate the origin of enamel
TLDR
It is shown that Psarolepis romeri, a bony fish from the the Early Devonian period, combines enamel-covered dermal odontodes on scales and skull bones with teeth of naked dentine, and that Lepisosteus oculatus (the spotted gar) has enam and ambn genes that are expressed in the skin, probably associated with ganoine formation. Expand
Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.
TLDR
An overall roadmap of the repertoire of the SLC25 family in mammals is provided, showing that there are at least 46 genes in the human genome coding for mitochondrial transporters. Expand
Further evidence for ancient role of ACTH peptides at melanocortin (MC) receptors; pharmacology of dogfish and lamprey peptides at dogfish MC receptors
TLDR
The results provide the first evidence that native ACTH ligands from dogfish and lamprey have a preference above native MSH peptides to ancient version of the MC3 and MC4 receptors, which strengthens the hypotheses that the ligand contributing to the first version ofThe melanocortin ligand-receptor system resembled ACTH. Expand
Evolutionary conservation of the structural, pharmacological, and genomic characteristics of the melanocortin receptor subtypes
TLDR
The MCRs serve as an interesting model family to understand the molecular mechanisms of how functions of the genes can diverge during evolution and are provided as an overview of recent studies on the cloning, expression, pharmacology, 3D modeling, and genomic studies of the M CRs in non-mammalian species. Expand
Gene structure of the goldfish agouti-signaling protein: a putative role in the dorsal-ventral pigment pattern of fish.
TLDR
These studies support agouti signaling protein as the melanization inhibition factor, a key factor in the development of the dorsal-ventral pigment pattern in fish. Expand
Differential regulation of nuclear receptors, neuropeptides and peptide hormones in the hypothalamus and pituitary of food restricted rats.
TLDR
A map of how food restriction affects the regulation of a number of transcripts involved in neuroendocrine control is provided, using real-time quantitative polymerase chain reaction (PCR) to validate the experimental conditions for several house-keeping genes. Expand
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