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Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone
An understanding of the regulators of neurogenesis in the normal and diseased brain is necessary in order to recruit endogenously produced neural precursors for cell replacement in neurodegenerativeExpand
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Degenerative and spontaneous regenerative processes after spinal cord injury.
Spinal cord injury results in acute as well as progressive secondary destruction of local and distant nervous tissue through a number of degenerative mechanisms. Spinal cord injury also initiates aExpand
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Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation
Discrete regions of the adult CNS, including the subventricular zone (SVZ), do retain the capacity for neurogenesis. These progenitor cells may represent a potential new source of cells forExpand
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Ciliary Neurotrophic Factor Mediates Dopamine D2 Receptor-Induced CNS Neurogenesis in Adult Mice
Neurogenesis continues in the adult forebrain subventricular zone (SVZ) and the dentate gyrus of the hippocampal formation. Degeneration of dopaminergic projections in Parkinson's disease and animalsExpand
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Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury.
Blood vessel loss and inflammation cause secondary degeneration following spinal cord injury. Angiopoietin-1 through the Tie2 receptor, and other ligands through alphavbeta3 integrin, promoteExpand
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Molecular regulation of adult CNS neurogenesis: an integrated view
  • T. Hagg
  • Biology, Medicine
  • Trends in Neurosciences
  • 1 November 2005
Neural stem cells in the adult subventricular zone and dentate gyrus might be utilized to replace lost neurons in neurological disorders. The development of treatments would be facilitated byExpand
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The ADAMs family: Coordinators of nervous system development, plasticity and repair
A disintegrin and metalloprotease (ADAM) transmembrane proteins have metalloprotease, integrin-binding, intracellular signaling and cell adhesion activities. In contrast to other metalloproteases,Expand
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alpha6beta1 integrin directs migration of neuronal precursors in adult mouse forebrain.
New neuroblasts are constantly generated in the adult mammalian subventricular zone (SVZ) and migrate via the very-restricted rostral migratory stream (RMS) to the olfactory bulb, where theyExpand
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A Positive Feedback Loop between Glycogen Synthase Kinase 3β and Protein Phosphatase 1 after Stimulation of NR2B NMDA Receptors in Forebrain Neurons*
N-methyl-d-aspartate receptors (NMDARs) are critical for neuronal plasticity and survival, whereas their excessive activation produces excitotoxicity and may accelerate neurodegeneration. Here, weExpand
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Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse
After traumatic spinal cord injury (SCI), disruption and plasticity of the microvasculature within injured spinal tissue contribute to the pathological cascades associated with the evolution of bothExpand
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