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Global and Local Determinants for the Kinetics of Interleukin‐4/Interleukin‐4 Receptor α Chain Interaction
An engineered interleukin-4-binding protein (IL4-BP) representing the extracellular domain of the human interleukin-4 (IL-4) receptor α chain was expressed in Sf9 cells. The purified IL4-BP wasExpand
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Crystal Structure of the Interleukin-4/Receptor α Chain Complex Reveals a Mosaic Binding Interface
Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain ofExpand
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Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein.
An engineered interleukin-4-binding protein (IL4-BP) representing the extracellular domain of the human interleukin-4 (IL-4) receptor alpha chain was expressed in Sf9 cells. The purified IL4-BP wasExpand
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Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.
The identification of highly potent and orally active phenylpyrazines for the inhibition of PDE10A is reported. The new analogues exhibit subnanomolar potency for PDE10A, demonstrate high selectivityExpand
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Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
Novel imidazo[1,5-a]pyrido[3,2-e]pyrazines have been synthesized and characterized as both potent and selective phosphodiesterase 10A (PDE10A) inhibitors. For in vitro characterization, inhibition ofExpand
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Tissue-Specific Fatty Acid Composition of Glandular Trichomes of Mite-Resistant and -Susceptible Pelargonium xhortorum
Anacardic acids, alkyl phenolic acids excreted by tall glandular trichomes of the garden geranium, Pelargonium xhortorum, confer small-pest resistance. Up to 90% of the trichome exudate fromExpand
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RNA-Based Drug Screening Using Automated RNA Purification and Real-time RT-PCR1
A new system has been developed for RNA-based drug screening, and the feasibility of this approach has been demonstrated by the identification of new immunomodulating compounds. Peripheral bloodExpand
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Crystals of a 1:1 complex between human interleukin-4 and the extracellular domain of its receptor alpha chain.
The specific high-affinity binding of interleukin-4 (IL-4) to its receptor alpha chain is the crucial primary event during IL-4 signalling. Single crystals, suitable for high resolution diffractionExpand
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