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The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis.
The mouse Dmc1 gene is an E. coli RecA homolog that is specifically expressed in meiosis. The DMC1 protein was detected in leptotene-to-zygotene spermatocytes, when homolog pairing likely initiates.Expand
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Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement.
Autosomal-dominant spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative disorders. In this study, we performed genetic analysis of a unique form of SCA (SCA36) that isExpand
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The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis.
Genetic recombination in meiosis plays an important role in generating diversity of genetic information. In yeast an Escherichia coli RecA-like gene, DMC1, is expressed in meiotic prophase and itsExpand
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The association of ATR protein with mouse meiotic chromosome cores
Abstract. The ATR (ataxia telangiectasia- and RAD3-related) protein is present on meiotic prophase chromosome cores and paired cores (synaptonemal complexes, SCs). Its striking characteristic is thatExpand
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A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules.
Mal3 is a fission yeast homolog of EB1, a plus-end tracking protein (+TIP). We have generated a mutation (89R) replacing glutamine with arginine in the calponin homology (CH) domain of Mal3. AnalysisExpand
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Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins
Polζ, a DNA polymerase specialized for translesion DNA synthesis (TLS), is comprised of two subunits, the REV3 catalytic subunit and the REV7 accessory subunit. The human REV7 (hREV7) protein isExpand
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p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis.
The tumor suppressor protein p53 is specifically expressed during meiosis in spermatocytes. Subsets of p53 knockout mice exhibit testicular giant cell degenerative syndrome, which suggests p53 may beExpand
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RNF213 Rare Variants in Slovakian and Czech Moyamoya Disease Patients
RNF213/Mysterin has been identified as a susceptibility gene for moyamoya disease, a cerebrovascular disease characterized by occlusive lesions in the circle of Willis. The p.R4810K (rs112735431)Expand
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Chromosome mapping of the mouse homologue ofDMC1, the yeast meiosis-specific homologous recombination gene
As i l lustrated in Figures 1 and 2, the hybr id iza t ion signals are visible as clusters of black dots in the vicinity of the a t tachment plaques. The morpho logy of the SCs has been wellExpand
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p 53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC 1 in meiosis
Toshiyuki Habu, Nobunao Wakabayashi, Kayo Yoshida, Kenntaro Yomogida, Yoshitake Nishimune and Takashi Morita Department of Molecular Embryology, Research Institute for Microbial Diseases, OsakaExpand
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