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Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.
The short term cardiac side-effects of AZT (3'-azido-3'-deoxythymidine, zidovudine) was studied in rats to understand the biochemical events contributing to the development of AZT-inducedExpand
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Prevention of Doxorubicin-Induced Acute Cardiotoxicity by an Experimental Antioxidant Compound
Doxorubicin is a widely used anticancer agent, but its application is restricted by its cardiotoxic side effects. The current theory of its cardiotoxicity is based on free radical formation. TheExpand
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Effect of L-2286, a Poly(ADP-ribose)polymerase Inhibitor and Enalapril on Myocardial Remodeling and Heart Failure
Increased activation of poly(ADP-ribose) polymerase (PARP) enzyme has been implicated in the pathogenesis of acute and chronic myocardial dysfunction. We have demonstrated the protective effect ofExpand
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The effect of carvedilol on enhanced ADP-ribosylation and red blood cell membrane damage caused by free radicals.
OBJECTIVE Previous studies have reported that the beta and alpha adrenoceptor blocker carvedilol has unique protective effects on free radical-induced myocardial injury. The aim of this study was toExpand
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The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis
Elevated serum triglyceride concentration (seTG, >1.7 mM or >150 mg/dL) or in other words hypertriglyceridemia (HTG) is common in the populations of developed countries. This condition is accompaniedExpand
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Orally given gastroprotective capsaicin does not modify aspirin-induced platelet aggregation in healthy male volunteers (human phase I examination).
Capsaicin is a well-known component of red pepper. Recent studies have shown that capsaicin could prevent gastric ulcer provoked by various NSAID-s like acetylsalicylic acid (ASA). Primary objectiveExpand
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Cerebrovascularis támadáspontú gyógyszerek szabadgyökfogó hatásának vizsgálata.
INTRODUCTION Oxygen free radicals play an important role in several physiological and pathophysiological processes. In pathological circumstances they can modify and damage biological systems. AsExpand
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Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta‐analysis and systematic review
The prevalence of Helicobacter pylori infection (HPI) has been decreasing in developed countries, with an increasing prevalence of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) at theExpand
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Therapeutic Whole-Body Hypothermia Reduces Death in Severe Traumatic Brain Injury if the Cooling Index Is Sufficiently High: Meta-Analyses of the Effect of Single Cooling Parameters and Their
Therapeutic hypothermia was investigated repeatedly as a tool to improve the outcome of severe traumatic brain injury (TBI), but previous clinical trials and meta-analyses found contradictoryExpand
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Pancreatitis-Associated Genes and Pancreatic Cancer Risk
Objective The aim of this study was to evaluate the connection between pancreatic cancer (PC) and genetic variants associated with chronic pancreatitis via systematic review and meta-analysis.Expand
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