T. Haaf

Publications422
h-index54
Citations15,187
Highly Influential Citations692
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Epigenetic reprogramming in mouse primordial germ cells
Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early embryos, plays a crucial role in regulating genome functions at critical stages of development. We show here that mouse… Expand
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The DNA sequence of human chromosome 21
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live… Expand
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Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.
A sensitive and rapid in situ method was developed to visualize sites of single-stranded (ss) DNA in cultured cells and in experimental test animals. Anti-bromodeoxyuridine antibody recognizes the… Expand
  • 352
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Embryogenesis: Demethylation of the zygotic paternal genome
In mammals, both parental genomes undergo dramatic epigenetic changes after fertilization to form the diploid somatic genome. Here we show that the paternal genome in the mouse is significantly and… Expand
  • 1,240
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A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes
The genes that determine the development of the male or female sex are known in Caenorhabditis elegans, Drosophila, and most mammals. In many other organisms the existence of sex-determining factors… Expand
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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.
Rad51 protein of Saccharomyces cerevisiae is a structural homolog of the Escherichia coli recombination enzyme RecA. In yeast, the Rad51 protein is required for mitotic and meiotic recombination and… Expand
  • 527
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Chromosome banding in Amphibia
The somatic and meiotic chromosomes of the South American leptodactylid toads Odontophrynus americanus, Ceratophrys ornata, and C. cranwelli were analysed both with conventional staining and… Expand
  • 196
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Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA.
Replication protein A (RPA), a heterotrimeric single-stranded DNA binding protein, is required for recombination, and stimulates homologous pairing and DNA strand exchange promoted in vitro by human… Expand
  • 201
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Spatial Separation of Parental Genomes in Preimplantation Mouse Embryos
We have used two different experimental approaches to demonstrate topological separation of parental genomes in preimplantation mouse embryos: mouse eggs fertilized with 5-bromodeoxyuridine… Expand
  • 168
  • 13
Distribution of telomeric (TTAGGG)n sequences in avian chromosomes
Abstract. The physical ends of mammalian and other vertebrate chromosomes consist of tandemly repeated (TTAGGG)n hexamers, nucleating a specialized telomeric structure. However, (TTAGGG)n sequences… Expand
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