• Publications
  • Influence
Rip1 Mediates the Trif-dependent Toll-like Receptor 3- and 4-induced NF-κB Activation but Does Not Contribute to Interferon Regulatory Factor 3 Activation*
Rip1 is required for IκB kinase activation in response to tumor necrosis factor α (TNF-α) and has been implicated in the Toll-like receptor 3 (TLR3) response to double-stranded RNA. CytokineExpand
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The Strategy That Will Fix Health Care
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Patient quality of life during the 12 months following joint replacement surgery.
OBJECTIVE To determine whether preoperative characteristics influence quality of life outcomes 1, 6, and 12 months after joint replacement surgery. METHODS Patients (n = 222) with osteoarthritisExpand
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The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.
The death domain kinase Rip1 is recruited to the tumor necrosis factor receptor type 1 and mediates the IkappaB kinase and p38 MAP kinase pathways. In response to tumor necrosis factor-alphaExpand
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Evaluation of the Patient with Acute Chest Pain
The evaluation of acute chest pain remains challenging, despite many insights and innovations over the past two decades. The percentage of patients who present at the emergency department with acuteExpand
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Turning doctors into leaders.
  • T. H. Lee
  • Business, Medicine
  • Harvard business review
  • 1 April 2010
Traditional physicians see themselves as courageous lone healers, but they're working in a chaotic, performance-blind system. They need to function as part of a team and measure themselves accordingExpand
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  • Open Access
Standardizing Patient Outcomes Measurement.
Acceleration of outcomes measurement can unlock the potential of value-based health care for driving improvement. It requires a commitment to measuring a minimum sufficient set of outcomes for everyExpand
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  • Open Access
Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo
The serine/threonine kinase RIPK1 is recruited to TNFR1 to mediate proinflammatory signaling and to regulate TNF-induced cell death. A RIPK1 deficiency results in perinatal lethality, impaired NFκBExpand
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Cyclin activation of p34
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Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon.
The chemotactic cytokine interleukin 8 (IL-8) is produced upon stimulation by various agents in many cell types, including connective-tissue fibroblasts. Tumor necrosis factor (TNF) and IL-1 areExpand
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  • Open Access